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Novel Protein-Based Sensors Rapidly Detect Coronavirus Antibodies Written by AZoSensorsJan 29 2021 A new method has been developed by researchers to detect the proteins that constitute the pandemic coronavirus, along with its antibodies. They created protein-based biosensors that glow on combining with components of the virus or particular COVID-19 antibodies. Illustration of a biosensor detecting a targeted molecule and glowing. Image Credit: Ian Haydon. This discovery could allow quicker and more extensive testing in the forthcoming days. The study has been published in the Nature journal. At present, a majority of the medical labs depend on a method known as RT-PCR for the diagnosis of coronavirus infection. The method involves amplifying genetic material from the virus so that it can be viewed and needs specialized equipment and staff. Moreover, it consumes laboratory supplies that are currently in high demand worldwide. Supply-chain shortages have dec ....
E-Mail IMAGE: An illustration of a new biosensor binding to a targeted molecule and emitting light. The creation of the biosensor was led by the UW Medicine Institute for Protein Design. view more Credit: Ian Haydon/UW Medicine Institute for Protein Design Scientists have created a new way to detect the proteins that make up the pandemic coronavirus, as well as antibodies against it. They designed protein-based biosensors that glow when mixed with components of the virus or specific COVID-19 antibodies. This breakthrough could enable faster and more widespread testing in the near future. The research appears in Nature. To diagnose coronavirus infection today, most medical laboratories rely on a technique called RT-PCR, which amplifies genetic material from the virus so that it can be seen. This technique requires specialized staff and equipment. It also consumes lab supplies that are now in high demand all over the world. Supply-chain shortfa ....
Credits: Courtesy of the researchers Previous image Next image Using a novel technique for expanding tissue, MIT and Harvard Medical School researchers have devised a way to label individual molecules of messenger RNA within a tissue sample and then sequence the RNA. This approach offers a unique snapshot of which genes are being expressed in different parts of a cell, and could allow scientists to learn much more about how gene expression is influenced by a cell’s location or its interactions with nearby cells. The technique could also be useful for mapping cells in the brain or other tissues and classifying them according to their function. ....
Robyn Beck/AFP/Getty Images This story is part of a group of stories called Finding the best ways to do good. Soon after news broke that Elon Musk surpassed Jeff Bezos to become the world’s richest person, the Tesla and SpaceX CEO asked for guidance on “ways to donate money that really make a difference,” noting on Twitter that it’s “way harder than it seems.” With his request for advice, Musk instantly became one of the most interesting philanthropists in the world. In 2012, he signed the Giving Pledge, promising to give away at least half his fortune during his lifetime. His for-profit endeavors, which include electric cars and private spaceflight, have won a following among consumers who have hailed their purported social and environmental impact as much as their private benefits. But on the whole, during Musk’s meteoric climb to become the richest man alive, his giving has been sporadic, scattershot, and somewhat unstrategic. ....
The virus SARS-CoV-2, which causes COVID-19. Sanford Burnham Prebys Medical Discovery Institute Senior study author Sumit Chanda, Ph.D., director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys. Previous Next Newswise LA JOLLA, CALIF. – Jan 12, 2020 – Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it’s time to mount an antiviral response. The study, published today in Cell Reports, provides insights into the molecular basis of severe disease and may enable new strategies for the treatment and prevention of COVID-19. “Our research has shown that MDA-5 is the immune cop that’s tasked to keep an eye out for SARS-CoV-2 and call for back-up,” says Sumit Chanda, Ph.D., director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and senior author of the study. “MDA-5 recognizes replicating viruses in ....