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Vaccines delivered via skin may offer better protection against respiratory diseases


Vaccines delivered via skin may offer better protection against respiratory diseases
Among infectious diseases that have caused pandemics and epidemics, smallpox stands out as a success story. Smallpox vaccination led to the disease s eradication in the twentieth century. Until very recently, smallpox vaccine was delivered using a technique known as skin scarification (s.s.), in which the skin is repeatedly scratched with a needle before a solution of the vaccine is applied. Almost all other vaccines today are delivered via intramuscular injection, with a needle going directly into the muscle, or through subcutaneous injection to the layer of tissue beneath the skin. ....

Thomas Kupper , Emily Henderson , Drug Administration , Department Of Dermatology , Infectious Diseases , தாமஸ் குப்பேர் , எமிலி ஹென்டர்சன் , துறை ஆஃப் தோல் நோய் , தோல் நோய் , தொற்று நோய்கள் ,

Genetic interactions may shed light on NGLY1 deficiency


Genetic interactions may shed light on NGLY1 deficiency
In 2012, four-year-old Bertrand Might became the first-ever patient diagnosed with a rare genetic disorder called N-glycanase (NGLY1) deficiency. The discovery of this condition and Bertrand s diagnosis allowed doctors to look for other children with the same genetic defect. Since then, more than 60 additional patients have been found.
The disease affects every system of the body and is characterized by low muscle tone, seizures, developmental delays, and an inability to produce tears.
Sadly, Bertrand passed away in October at the age of 12. Although his life was cut short, his legacy will benefit children around the world. Through their website, NGLY1.org, Bertrand s parents collect and share a wealth of research and family stories to help educate and inform the community. As more patients have been identified, it s become apparent that even though the same gene is deactivated in all of them, their symptoms and s ....

Clement Chow , Emily Henderson , University Of Utah Health , Drosophila Genetic Reference Panel , Department Of Human Genetics , Bertrand Might , Human Genetics , Utah Health , Drosophila Genetic Reference , Assistant Professor , Genetic Disorder , Ngly1 Deficiency , கிளெமென்ட் சோவ் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் உட்டா ஆரோக்கியம் , துறை ஆஃப் மனிதன் ஜெநெடிக்ஸ் , பெர்ட்ராண்ட் வலிமை , மனிதன் ஜெநெடிக்ஸ் , உட்டா ஆரோக்கியம் , உதவியாளர் ப்ரொஃபெஸர் , ஜெநெடிக் கோளாறு ,