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Genes that dance to circadian rhythm


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Genes that dance to circadian rhythm
Scientists at EPFL have made breakthrough discoveries on the circadian clock and how it affects gene expression. Some of the findings suggest a biological underpinning for different behaviors in people, such as morning people, nappers, evening people, night owls etc.
In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the “wake-sleep” cycle. To carry out their work, the scientists used the common fruit fly Drosophila melanogaster, making this the sixth Nobel to be awarded to research involving it. ....

Bart Deplancke , Maria Litovchenko , Charlesw Woodworth , Thomash Morgan , School Of Life Sciences , Swiss Institute Of Bioinformatics , Drosophila Genetic Reference Panel , Brandeis University , Fly Room At Columbia University , Nobel Prize , Fly Room , Columbia University , Life Sciences , Science Advances , Circadian Rhythm , Agenetic Mutation , Fruit Flies , தோமாஷ் மோர்கன் , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , சுவிஸ் நிறுவனம் ஆஃப் உயிர் தகவலியல் , பிராண்டீஸ் பல்கலைக்கழகம் , ஈ அறை இல் கொலம்பியா பல்கலைக்கழகம் , நோபல் ப்ரைஸ் , ஈ அறை , கொலம்பியா பல்கலைக்கழகம் , வாழ்க்கை அறிவியல் ,

Scientists study how different genes dance to the circadian rhythm


Scientists study how different genes dance to the circadian rhythm
In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the wake-sleep cycle. To carry out their work, the scientists used the common fruit fly
Drosophila melanogaster, making this the sixth Nobel to be awarded to research involving it.
Fruitful fruit flies
Life scientists have been using
Drosophila for over a century now. First proposed by entomologist Charles W. Woodworth as a model organism, its use in research was pioneered by geneticist Thomas H. Morgan who ran his famous Fly Room at Columbia University in the early 1900 s. ....

Bart Deplancke , Maria Litovchenko , Charlesw Woodworth , Emily Henderson , Thomash Morgan , School Of Life Sciences , Drosophila Genetic Reference Panel , Fly Room At Columbia University , Nobel Prize , Fly Room , Columbia University , Life Sciences , Circadian Rhythm , Gene Expression , எமிலி ஹென்டர்சன் , தோமாஷ் மோர்கன் , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , ஈ அறை இல் கொலம்பியா பல்கலைக்கழகம் , நோபல் ப்ரைஸ் , ஈ அறை , கொலம்பியா பல்கலைக்கழகம் , வாழ்க்கை அறிவியல் , சர்க்காடியன் தாளம் , கீந் வெளிப்பாடு ,

Genes that dance to the circadian rhythm


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In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the wake-sleep cycle. To carry out their work, the scientists used the common fruit fly Drosophila melanogaster, making this the sixth Nobel to be awarded to research involving it.
Fruitful fruit flies
Life scientists have been using Drosophila for over a century now. First proposed by entomologist Charles W. Woodworth as a model organism, its use in research was pioneered by geneticist Thomas H. Morgan who ran his famous Fly Room at Columbia University in the early 1900 s. ....

Bart Deplancke , Maria Litovchenko , Charlesw Woodworth , Thomash Morgan , School Of Life Sciences , Swiss Institute Of Bioinformatics , Drosophila Genetic Reference Panel , Brandeis University , Fly Room At Columbia University , Nobel Prize , Fly Room , Columbia University , Life Sciences , தோமாஷ் மோர்கன் , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , சுவிஸ் நிறுவனம் ஆஃப் உயிர் தகவலியல் , பிராண்டீஸ் பல்கலைக்கழகம் , ஈ அறை இல் கொலம்பியா பல்கலைக்கழகம் , நோபல் ப்ரைஸ் , ஈ அறை , கொலம்பியா பல்கலைக்கழகம் , வாழ்க்கை அறிவியல் ,

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior


w
1118. (
B) Heatmap of the expression of TSC genes averaged across 2 days of observation. The presence of the characteristic circadian patterns in the tissue is indicated with black rectangles around the heatmaps. The number at the left designates the number of detected TSC genes. (
C and
D) Heatmap of cycling in two (C) and three tissues (D) gene expression averaged across 2 days of observation. Black rectangles indicate tissues in which genes were found to be cycling. For (B) to (D), lighter areas or the heatmaps correspond to lower expression levels. The time is indicated at the bottom of the heatmap. ( ....

Picard Addorreplacereadgroups , Picard Markduplicates , European Community Framework Programme , Drosophila Genetic Reference Panel , Vienna Drosophila Resource Center , University Of Iowa , Bloomington Stock Center , Reagent Molecular Research Center , Development Studies Hybridoma Bank , Zymo Research , Genetic Reference Panel , Drosophila Malpighian , Vienna Drosophila Resource , Zeitgeber Time , Molecular Research Center , Quant It Ribogreen , Thermo Fisher Scientific , Illumina Hiseq , Alexa Fluor , Genome Analysis Toolkit , Refseq Genes , Supporting Table , Creative Commons Attribution , Marie Curie Intra European Fellowship , Seventh European Community Framework , Expression Omnibus ,