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Frontiers | Developmental Alcohol Exposure in Drosophila: Effects on Adult Phenotypes and Gene Expression in the Brain

Frontiers | Developmental Alcohol Exposure in Drosophila: Effects on Adult Phenotypes and Gene Expression in the Brain
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United States , Prenat Diagn , Agilent Tapestation , Santa Clara , Centers For Disease , Institute Of Medicine , National Institutes Of Health , Alcohol Res Health , Life Sciences Congress , Disease Control , Drosophila Activity Monitors , Single Cell , Illumina Novaseq , Data Analysis , Cell Ranger , Developmental Alcohol Exposure , Supplementary Table , Supplementary Tables , Supplementary Figure , National Institutes , Supplementary Material , Med Abstract , Crossref Full Text , Alcohol Clin Exp , Int Neuropsychol , Clin Exp ,

Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury

Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury
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New York , United States , United Kingdom , Baden Wüberg , Bergisch Gladbach , Nordrhein Westfalen , Masaomi Nangaku , Rieko Matsuda , Miltenyi Biotec , Naoki Kuramoto , Hirokir Ueda , Toshiyuki Ko , Tanabe Ea Susaki , Etsuoa Susaki , Atsuko Nakanishi Ozeki , Shintaro Yamada , Imaris Bitplane , Yu Hirata , Daichi Fukaya , Takashi Taguchi , Issei Komuro , Youichiro Wada , Tsuyoshi Inoue , Wachirasek Peerapanyasut , Sayaka Hayashi , Seitaro Nomura ,

A nonviral, nonintegrating DNA nanovector platform for the safe, rapid, and persistent manufacture of recombinant T cells

Abstract
The compelling need to provide adoptive cell therapy (ACT) to an increasing number of oncology patients within a meaningful therapeutic window makes the development of an efficient, fast, versatile, and safe genetic tool for creating recombinant T cells indispensable. In this study, we used nonintegrating minimally sized DNA vectors with an enhanced capability of generating genetically modified cells, and we demonstrate that they can be efficiently used to engineer human T lymphocytes. This vector platform contains no viral components and is capable of replicating extrachromosomally in the nucleus of dividing cells, providing persistent transgene expression in human T cells without affecting their behavior and molecular integrity. We use this technology to provide a manufacturing protocol to quickly generate chimeric antigen receptor (CAR)–T cells at clinical scale in a closed system and demonstrate their enhanced anti-tumor activity in vitro and in vivo in comparis ....

Amersham Bioscience , D Trono Addgene , Texmacs Miltenyi Biotec , Miltenyi Biotec , Lumikine Xpress , Jackson Immunoresearch , Maxcyte Gtx , Panreac Applichem , Deutsches Krebsforschungszentrum , Elevator Pitch Programme Of The National Center , Bd Sciences , Drug Administration , Agilent Technologies , Proof Of Concept Program , Deutsches Krebsforschungszentrum German Cancer Research Center , Nature Technology Corporation , Jackson Laboratory , Heidelberg University Hospital Blood Bank , Stellar Competent Cells , Life Technologies , Leinco Technologies , Acro Biosystems , Alexa Fluor , Tissue Extraction , Thermo Fisher Scientific , Loading Dye ,

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis
Michael David Brügger ,
Contributed equally to this work with:
Michael David Brügger,
Tomas Valenta,
Hassan Fazilaty
Roles
Conceptualization,
Data curation,
Formal analysis,
Funding acquisition,
Investigation,
Methodology,
Software,
Visualization,
Writing – original draft,
Writing – review & editing
Affiliation
Department of Molecular Life Sciences, University of Zurich, Switzerland
Roles
Conceptualization,
Funding acquisition,
Investigation,
Methodology,
Supervision,
Writing – review & editing
Roles
Conceptualization,
Data curation,
Formal analysis,
Software,
Visualization,
Writing – review & editing
Affiliation
....

United States , United Kingdom , Chemcruz Santa Cruz , Vimentin Millipore , Octo Dissociator Miltenyi Biotec , Bioscience Thermofisher , L Dispase Gibco , Cytometry Facility Of University Zurich , Genomics Center Zurich , Cantonal Veterinary Office , Genomics Center , Model Fig , Swiss Guidelines , Charles River , Jackson Laboratories , Gentle Cell Dissociation Reagent , Miltenyi Biotec , Zombie Violet Fixable Viability Kit , Cytometry Facility , Single Cell , Chromium Controller , Santa Cruz Biotechnology , Biosystems Switzerland , Thermo Fisher Scientific , Alexa Dyes , Advanced Cell Diagnostics ,