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TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders

TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders
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Texas Team s Wastewater Surveillance Can Pick Up Concerning H5N1 Mutations

Azenta Opens the Doors to Its New Genomics Laboratory in Oxford, UK

Azenta Opens the Doors to Its New Genomics Laboratory in Oxford, UK
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Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women
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Salicylic acid enhances cell growth, fatty acid and astaxanthin production in heterotrophic Chromochloris zofingiensis without reactive oxygen species elevation | Biotechnology for Biofuels and Bioproducts

The induction of lipid and astaxanthin accumulation in microalgae is often achieved through abiotic stress. However, this approach usually leads to oxidative stress, which results in relatively low growth rate. Phytohormones, as important small molecule signaling substances, not only affect the growth and metabolism of microalgae but also influence the intracellular reactive oxygen species level. This study aimed to screen phytohormones that could promote the fatty acids and astaxanthin yield of heterotrophic Chromochloris zofingiensis without causing oxidative damage, and further investigate the underlying mechanisms. In the present study, among all the selected phytohormones, the addition of exogenous salicylic acid (SA) could effectively promote cell growth along with the yield of total fatty acids (TFA) and astaxanthin in heterotrophic C. zofingiensis. Notably, the highest yields of TFA and astaxanthin were achieved at 100 μM SA, 43% and 97.2% higher compared with the

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