RNA sequencing is a powerful technology for studying cells and diseases. In particular, single-cell RNA sequencing helps uncover the heterogeneity and diversity of our body.
RNA sequencing is a powerful technology for studying cells and diseases. Scientists from the research group of Christoph Bock, principal investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and professor at the Medical University of Vienna, developed a new method for sequencing huge numbers of single cells in an efficient manner. The study has now been published in Nature Methods.
Credit: Tatjana Hirschmugl
A new study exploits the characteristic epigenetic signatures of childhood tumors to detect, classify and monitor the disease. The scientists analyzed short fragments of tumor DNA that are circulating in the blood. These liquid biopsy analyses exploit the unique epigenetic landscape of bone tumors and do not depend on any genetic alterations, which are rare in childhood cancers. This approach promises to improve personalized diagnostics and, possibly, future therapies of childhood tumors such as Ewing sarcoma. The study has been published in
Nature Communications.
A study led by scientists from St. Anna Children s Cancer Research Institute (St. Anna CCRI) in collaboration with CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences provides an innovative method for liquid biopsy analysis of childhood tumors. This method exploits the fragmentation patterns of the small DNA fragments that tumors leak into the blood stream, whi
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New research highlights importance of thymus in successful pregnancies
How the immune system adapts to pregnancies has puzzled scientists for decades. Now, findings from an international group of researchers, led by researchers at Karolinska Institutet in Sweden, reveal important changes that occur in the thymus to prevent miscarriages and gestational diabetes. The results are published in the journal Nature.
The thymus is a central organ of the immune system where specialised immune cells called T lymphocytes mature. These cells, commonly referred to as T cells, then migrate into the blood stream and tissues to help combat pathogens and cancer. An important T cell subset, known as a regulatory T cell or Treg, is also produced in the thymus. The main function of a Treg is to help regulate other immune cells.