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Immune cells on standby are constantly stimulated by healthy tissue, new study finds

Immune cells on standby are constantly stimulated by healthy tissue, new study finds
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Christoph bockMatthias farlikNikolaus fortelnyKlaus pichlerUniversity of veterinary medicine viennaUniversity of salzburgUniversity of viennaPrincipal investigatorMedical universityThomas deckerMax perutz labsVeterinary medicine viennaNature immunology

Immune Cells Stay on Standby to Defend Immune System

Immune Cells Stay on Standby to Defend Immune System
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Christoph bockMatthias farlikNikolaus fortelnyThomas deckerCemm research centerUniversity of veterinary medicine viennaUniversity of salzburgUniversity of viennaMolecular medicineAustrian academyNature immunologyMedical universityMax perutz labsVeterinary medicine

Vaccine Revives Dormant Immune Cells, Enhances Innate Immunity

Vaccine Revives Dormant Immune Cells, Enhances Innate Immunity
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United statesMihai neteaChristoph bockErwin schrChristoph bock cemm medical university of viennaInfectious diseases society of americaNetherlands royal academy of sciencesMihai netea radboud university medical centerHuman cell atlas organizing committeePrize of the austrian academy sciencesDepartment of internal medicineRadboud university medical centerUniversity of viennaCemm research centerEuropean lab forEuropean union horizon

Vaccine boosts innate immunity in people with dormant immune cells, finds study

Vaccine boosts innate immunity in people with dormant immune cells, finds study
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Christoph bock cemm medical university of viennaMihai netea radboud university medical centerMihai neteaRadboud university medical centerChristoph bock

Vaccine boosts innate immunity in people with

Bacillus Calmette-Guérin (BCG) is one of the world’s oldest and most widely used vaccines. It was developed in the early 20th century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity. A new study led by Christoph Bock and Mihai Netea found that epigenetic cell states predict whether or not an individual profits from the “wake-up call” to the innate immune system that is provided by the BCG vaccine. This discovery contributes to the development of future therapeutics that induce protective trained immunity.

United statesChristoph bockErwin schrMihai neteaStefan bernhardtNetherlands royal academy of sciencesCemm research centerUniversity of viennaChristoph bock cemm medical university of viennaRadboud university medical centerEuropean research councilMihai netea radboud university medical centerDepartment of internal medicinePrize of the austrian academy sciencesResearch centerAustrian academy of sciences