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IMAGE: The T cell (yellow) touches the antigen-presenting cell. Tiny forces are applied on the surface, eventually the connection breaks. view more
Credit: TU Wien / MedUni Wien
T-cells play a central role in our immune system: by means of their so-called T-cell receptors (TCR) they make out dangerous invaders or cancer cells in the body and then trigger an immune reaction. On a molecular level, this recognition process is still not sufficiently understood.
Intriguing observations have now been made by an interdisciplinary Viennese team of immunologists, biochemists and biophysicists. In a joint project funded by the Vienna Science and Technology Fund and the FWF, they investigated which mechanical processes take place when an antigen is recognized: As T cells move their TCRs pull on the antigen with a tiny force - about five pico-newtons (5 x 10-12 or 0.0000000005 newtons). This is not only sufficient to break the bonds between the TCRs and the antigen, it a
Updated:
March 08, 2021 15:26 IST
The researchers sequenced 750 genomes of the novel coronavirus from infected individuals and analysed the mutations
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Artistic 3D-rendering of a T cell fighting with SARS-CoV-2 (not to scale). Credit: Benedikt Agerer / CeMM
The researchers sequenced 750 genomes of the novel coronavirus from infected individuals and analysed the mutations Some mutations in the novel coronavirus may not only enable it to evade antibodies, but also make the virus unrecognisable to the immune system s T-killer cells, says a new study which could aid in the further development of vaccines.
While antibodies dock directly onto viruses to neutralise them, the scientists, including those from the Medical University of Vienna in Austria, said the T-killer cells recognise viral protein fragments on infected cells and subsequently kill them to stop virus production.
a recent sudy suggests certain mutations in the novel coronavirus may not only allow it to escape neutralisation but also make the virus unidentifiable to the immune system's T-killer' cells, which could aid in the further development of vaccines.
Some coronavirus mutations may help it evade immune system s T-killer cells, say scientists
The researchers sequenced 750 genomes of the novel coronavirus from infected individuals and analysed mutations for their potential to alter T cell epitopes.
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LONDON: Some mutations in the novel coronavirus may not only enable it to evade antibodies, but also make the virus unrecognisable to the immune system s T-killer cells, says a new study which could aid in the further development of vaccines.
While antibodies dock directly onto viruses to neutralise them, the scientists, including those from the Medical University of Vienna in Austria, said the T-killer cells recognise viral protein fragments on infected cells and subsequently kill them to stop virus production.
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