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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus s spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.

Science , abg5268, this issue p. [1108][1]

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-Co ....

United States , San Francisco , University Of California , Lamontagne Center , Ut System Proteomics Network , National Institute Of Allergy , Department Of Defense , Infectious Diseases Research Program , Sauer Structural Biology Laboratory , Us Army , Research Institute Of Texas , University Of Texas Board Regents , Centers For Disease , National Institutes Of Health , Electron Microscopy Data Bank , Department Of The Army , Welch Foundation , Protein Data Bank , University Of Texas College Natural Sciences , Clayton Foundation , Ig Seq Lin , United Kingdom , Creative Commons Attribution , Infectious Disease , Military Infectious Diseases Research Program , Disease Control ,

Immune system paints SARS-CoV-2 spike protein with antibodies


New research brings into focus the most complete picture yet of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection.
Researchers say the finding represents good news for designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses.
“There’s an evolutionary arms race going on between the virus and our immune systems.”
Previous research focused on one group of antibodies that target the most obvious part of the coronavirus’s spike protein, called the receptor-binding domain (RBD). Because the RBD is the part of the spike that attaches directly to human cells and enables the virus to infect them, researchers rightly assumed it to be a primary target of the immune system. ....

United States , Greg Ippolito , Jason Lavinder , Centers For Disease , Ut Austin Dell Medical School , University Of Texas At Austin , University Of North Carolina At Chapel Hill , National Institutes Of Health , Clayton Foundation , Welch Foundation , Dell Medical , North Carolina , Chapel Hill , Medical Research Institute , Infectious Diseases , Disease Control , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , கிரெக் இப்பொழித்தோ , மையங்கள் க்கு நோய் , உட் ஆஸ்டின் டெல் மருத்துவ பள்ளி , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் இல் ஆஸ்டின் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா இல் தேவாலயம் மலை , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , களிமண் அடித்தளம் , வெல்ச் அடித்தளம் ,