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New Clues Show How the Immune System Fights COVID By Brian Owens May 13, 2021 When the immune system detects an invading virus like COVID-19, it sends swarms of antibodies to latch on to it, blocking its ability to attach to cells and marking it for destruction by other cells. Now, new research shows in striking detail how that process works in people who have successfully recovered from COVID-19 and offers new insights to help others. So far, scientists have focused on one part of the coronavirus spike the receptor-binding domain which the virus uses to attach and gain access to human cells. This part of the coronavirus attaches directly to a person s cells to infect them, and is the part that researchers have made their top priority for vaccine and drug development. The monoclonal antibody therapies the FDA authorized last year use this same target. ....
New Clues Show How the Immune System Fights COVID-19 medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.
New research brings into focus the most complete picture yet of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. Researchers say the finding represents good news for designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses. “There’s an evolutionary arms race going on between the virus and our immune systems.” Previous research focused on one group of antibodies that target the most obvious part of the coronavirus’s spike protein, called the receptor-binding domain (RBD). Because the RBD is the part of the spike that attaches directly to human cells and enables the virus to infect them, researchers rightly assumed it to be a primary target of the immune system. ....
Antibodies cover entirety of SARS-CoV-2 Spike protein, study shows SHARES Researchers have found that over 80 percent of antibodies target sections of the SARS-CoV-2 Spike protein other than the RBD. Researchers at the University of Texas at Austin, US, have contributed to the developing picture of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralise the part of the virus responsible for causing infection. Previous research has focused on one group of antibodies that target a part of the Spike (S) protein called the receptor-binding domain (RBD). As the RBD is the part of the S protein that attaches directly to human cells and enables the virus to infect them, it was rightly assumed to be a primary target of the immune system. However, testing blood plasma samples from four people who recovered from SARS-CoV-2 infections, the researchers found that most of the antibodies circulating in the blood – on average, about 84 perc ....
Recent finding represents good news for designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses ....