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How to avoid a false negative when using an at-home COVID-19 test

At-home COVID-19 tests are quick, easy and convenient, but sometimes they can give a false negative result. Here are a few tips from an expert on how to get the most accurate results. ....

Centers For Disease , Lamontagne Center , University Of Texas , Jaquelin Dudley , Infectious Disease , Disease Control ,

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus s spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.

Science , abg5268, this issue p. [1108][1]

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-Co ....

United States , San Francisco , University Of California , Lamontagne Center , Ut System Proteomics Network , National Institute Of Allergy , Department Of Defense , Infectious Diseases Research Program , Sauer Structural Biology Laboratory , Us Army , Research Institute Of Texas , University Of Texas Board Regents , Centers For Disease , National Institutes Of Health , Electron Microscopy Data Bank , Department Of The Army , Welch Foundation , Protein Data Bank , University Of Texas College Natural Sciences , Clayton Foundation , Ig Seq Lin , United Kingdom , Creative Commons Attribution , Infectious Disease , Military Infectious Diseases Research Program , Disease Control ,