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PDC*line Pharma and Partners Receive €8 1M From Walloon Region and Wallonia Health Cluster BioWin for Personalized Therapeutic Vaccine Project

PDC*line Pharma and Partners Receive €8 1M From Walloon Region and Wallonia Health Cluster BioWin for Personalized Therapeutic Vaccine Project
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Osteoporosis drug also promotes infiltration of immune cells in breast tumors

Osteoporosis drug also promotes infiltration of immune cells in breast tumors The team of Eva González-Suarez, from the CNIO and IDIBELL, and the team of Christos Sotiriou, from the Jules Bordet Institute, demonstrate that a drug already used to treat osteoporosis promotes the infiltration of immune cells in breast tumors These findings propose a new target to increase the antitumor immune response and make breast cancer more sensitive to immunotherapy Despite the success of immunotherapy in the treatment of cancers such as lung or melanoma, it is still not effective in breast cancers for being cold , with low infiltration of immune cells.

The immunomodulatory activity of a drug would improve the efficacy of immunotherapy in breast cancer

Credit: IDIBELL Despite the success of immunotherapy in the treatment of cancers such as lung or melanoma, it is still not effective in breast cancers for being cold , with low infiltration of immune cells. Tumours use strategies to evade immune surveillance by reducing the infiltration of cells that could attack them or by attracting immunosuppressive cells. These strategies can contribute to the poor prognosis observed in breast cancer of young women and make them unresponsive to immunotherapy. For this reason, the identification of a therapy that could convert immunologically cold tumours -in which immunotherapy is not effective- into warm tumours would represent an important step to increase the efficiency of immunological therapies for breast cancer, since these are based on the reactivation of immune cells to attack tumour cells.

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