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E-Mail IMAGE: CtIP/Ctp1 stimulates endonuclease activity of the MRN complex, which not only polishes dirty ends of DNA breaks, but promotes accurate repair of DNA breaks through the homologous recombination mechanism. view more Credit: PNAS Scientists at Tokyo Institute of Technology (Tokyo Tech) have uncovered mechanisms underlying the activation of the MRN complex the cell s DNA scissors. Using purified yeast proteins, they demonstrated that phosphorylation of Ctp1, a homolog of a tumor-suppressor protein, plays a key role in activating MRN complex s DNA clipping activity. Intriguingly, a short segment of yeast Ctp1 or its human counterpart could stimulate endonuclease activity of their respective MRN complexes, suggesting its conserved function across species. ....
February 15, 2021 by Julie Parry In March of 2020, Shelli Farhadian, MD, PhD, assistant professor of medicine (infectious diseases) and neurology, began to see parallels in her pre-pandemic research on neurologic effects in patients with HIV infection and the possibility of neurologic effects on patients with SARS-CoV-2, or COVID-19. “There was some literature out there that suggested that coronaviruses could have an effect on the brain. So, knowing that that was a potential possibility, even before we had our first case at Yale New Haven Hospital, I worked with other people to set up a protocol where we could consent patients to collect tissue specimens and information to try to see if this was also going happen with SARS-CoV-2,” explained Farhadian. ....