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New antibody conjugate delivers drugs to bone tumors and inhibits metastasis

New antibody conjugate delivers drugs to bone tumors and inhibits metastasis
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Chenfei Yu , Lushun Wang , Chai Wang , Axel Loredo , Kuan Lin Wu , Weijie Zhang , Williamt Butler , Emily Henderson , Yuda Chen , Zhan Xu , Han Xiao , Igor Bado , Breast Cancer Research Foundation , Us Department Of Defense , Mcnair Medical Institute , Scholar In Cancer Research , Hamill Foundation , National Institutes Of Health , Roberta Welch Foundation , Johns Dunn Foundation , Sue Smith Breast Center , Danl Duncan Comprehensive Cancer Center , Rice University , Baylor College Of Medicine , Research Institute Of Texas , Baylor College ,

Drug Doubles Down on Bone Cancer, Metastasis

Drug Doubles Down on Bone Cancer, Metastasis
labmanager.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from labmanager.com Daily Mail and Mail on Sunday newspapers.

Rice University , United States , Baylor College Of Medicine , Chenfei Yu , Lushun Wang , Chai Wang , Axel Loredo , Kuan Lin Wu , Weijie Zhang , Williamt Butler , Yuda Chen , Zhan Xu , Igor Bado , Breast Cancer Research Foundation , Mcnair Medical Institute , Scholar In Cancer Research , Hamill Foundation , National Institutes Of Health , Roberta Welch Foundation , Johns Dunn Foundation , Sue Smith Breast Center , Danl Duncan Comprehensive Cancer Center , Us Department Of Defense , Research Institute Of Texas , Drug Doubles Down , Bone Cancer ,

Scientists discover 'jumping' genes that can protect against blood cancers

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IMAGE: Zhimin Gu, Ph.D., postdoctoral fellow, Children s Medical Center Research Institute at UT Southwestern (CRI), and Jian Xu Ph.D., associate professor, CRI
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Credit: UT Southwestern Medical Center
DALLAS - April 8, 2021 - New research has uncovered a surprising role for so-called jumping genes that are a source of genetic mutations responsible for a number of human diseases. In the new study from Children s Medical Center Research Institute at UT Southwestern (CRI), scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against certain blood cancers.
These findings, published in
Nature Genetics, led scientists to identify a new biomarker that could help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML), the deadliest type of blood cancer in adults and children. ....

United States , Yuxuan Liu , Alec Zhang , Jian Xu , John Abrams , Zhimin Gu , Scholar In Cancer Research , National Institutes Of Health , Children Medical Center Dallas , Leukemia Texas Foundation , American Society Of Hematology Scholar , Welch Foundation , Children Medical Center Research Institute , Ut Southwestern Medical Center , Children Medical Center Foundation , Leukemia Lymphoma Society Scholar , Children Health , Research Institute Of Texas , Dakota State University , Medical Center Research Institute , Nature Genetics , Cancer Prevention , Research Institute , South Dakota State , National Institutes , Lymphoma Society Scholar ,

Researchers identify mechanism by which exercise strengthens bones and immunity

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IMAGE: Deep imaging of a mouse femur bone marrow showing that Osteolectin-expressing cells (red) are around arterioles (white) but not sinusoids (green).
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Credit: UT Southwestern Medical Center
Scientists at the Children s Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study, published in
Nature, also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function. ....

Mary Mcdermott Cook , Bo Shen , Sean Morrison , National Academies Of Science , Leopoldina Fellowship Program , Scholar In Cancer Research , Pediatric Research At Children Institute , National Institutes Of Health , Howard Hughes Medical Institute Investigator , German National Academy Of Sciences , Children Medical Center Research Institute , Children Medical Center Foundation , Blood Institute , Ruthl Kirschstein National Research Service Award , National Heart , Research Institute Of Texas , Fritz Thyssen Foundation , Medical Center Research Institute , Howard Hughes Medical Institute , Cancer Prevention , Research Institute , Cancer Research , National Academies , Gene Bishop Distinguished Chair , Pediatric Research , Mary Mcdermott Cook Chair ,

Errant DNA boosts immunotherapy effectiveness

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IMAGE: A UT Southwestern study discovered the molecular mechanism by which tumors defective in DNA mismatch repair respond to immunotherapy. This illustration depicts how cells use a programmed mismatch repair deficiency-activated.
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Credit: Illustration by Yipin Wu
DALLAS - Dec. 17, 2020 - DNA that ends up where it doesn t belong in cancer cells can unleash an immune response that makes tumors more susceptible to immunotherapy, the results of two UT Southwestern studies indicate. The findings, published online today in
Cancer Cell, suggest that delivering radiation - which triggers DNA release from cells - before immunotherapy could be an effective way to fight cancers that are challenging to treat. ....

United States , Junqiu Zhang , Eugene Frenkel , Longchao Liu , Zhenhua Ren , Anthonyj Davis , Janice Ortega , Qihuang Jin , Tao Wang , Yong Liang , Xuezhi Cao , Ralphb Rogers , Huiming Lu , Axiang Chen , Zhida Liu , Jiankun Zhu , Junhong Guan , Reecea Overcash Jr , Mary Nell , Yang Xin Fu , Liya Gu , Chuanhui Han , Hongyi Zhang , Zhijianj Chen , Jerryw Shay , Jian Qiao ,