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Machine learning sheds light on gene transcription

Gene activity plays key role in immune cell production, study shows

As people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19.

How gene activity modulates the amount of immune cell production in mice

Stem cell study shows how gene activity modulates the amount of immune cell production in mice

USC Stem Cell study shows how gene activity m

<p style="text-align:start">In a new mouse study published in<em> Science Advances</em>, researchers from the USC Stem Cell lab of Rong Lu describe how specific gene activity could potentially enhance immune cell production. The researchers wanted to understand the mechanism of why some hematopoietic stem cells produce more immune cells, while other stem cells produce fewer. The research team pioneered new techniques for understanding the quantitative association between immune cell production and gene expression in lab mice. The scientists labeled individual stem cells with genetic &ldquo;barcodes&rdquo; to track their immune cell production. They then correlated the barcode tracking with measurements of gene expression activity. They also developed innovative bioinformatics approaches to characterize their quantitative association. The scientists identified nearly 40 genes that are related to immune cell production. They discovered associations bet