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A two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, could lead to new types of cancer immunotherapies. ....
E-Mail IMAGE: A UT Southwestern study discovered the molecular mechanism by which tumors defective in DNA mismatch repair respond to immunotherapy. This illustration depicts how cells use a programmed mismatch repair deficiency-activated. view more Credit: Illustration by Yipin Wu DALLAS - Dec. 17, 2020 - DNA that ends up where it doesn t belong in cancer cells can unleash an immune response that makes tumors more susceptible to immunotherapy, the results of two UT Southwestern studies indicate. The findings, published online today in Cancer Cell, suggest that delivering radiation - which triggers DNA release from cells - before immunotherapy could be an effective way to fight cancers that are challenging to treat. ....