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Unexpected proteome plasticity in response to persistent temperature rise

Unexpected proteome plasticity in response to persistent temperature rise
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , La Jolla , San Francisco , Matthew Domnaurer , Ying Zhang , Laurence Florens , Christopher Seidel , Jayr Unruh , Yanxiao Zhang , Julie Conkright Fincham , Catherinee Chang , Birgit Schilling , Kausik Si , Benjamin Fong , Scott Mccroskey , Arvind Ramanathan , University Of California , Stowers Institute For Medical Research , National Institutes Of Health , Other Buck Institute , Buck Institute Fellow Chuankai Kai Zhou , Stowers Institute , Buck Institute , Ludwig Institute For Cancer Research , Institute Fellow Chuankai , Fan Zheng ,

First actionable clock that predicts immunological health and chronic diseases of aging

First actionable clock that predicts immunological health and chronic diseases of aging
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Palo Alto , Stanford University , Region Flamande , South Korea , Russian Federation , Ayelet Alpert , Tianxiang Gao , Vladimir Jojic , Joseg Montoya , Rita Ostan , Holdent Maecker , Francois Haddad , Tatiana Kuznetsova , Robert Tibshirani , Lu Cui , Trevor Hastie , Tony Wyss , Khiem Nguyen , Benoit Lehallier , Daniela Monti , Claudio Franceschi , David Furman , Yingxiang Huang , Nazish Sayed , Josephc Wu ,

Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington s disease (HD) heightens the need for new approaches for the devastating, incurable, progressive neurodegenerative genetic disorder. Scientists at the Buck Institute have found that the targeting the protein called FK506-binding protein 51 or FKBP51 promotes the clearing of those toxic proteins via autophagy, a natural process whereby cells recycle damaged proteins and mitochondria and use them for nutrition. ....

Jesse Simons , Swati Naphade , Michellee Ehrlich , Ningzhe Zhang , Kuruwitage Lakshika Madushani , Stephen Scheeler , Feliz Hausch , Technische Universitat Darmstadt , Kathrineh Schreiber , Jordi Creus Muncunill , Felix Hausch , Mariaa Sanchez , Alejandro Lopez Ramirez , Barbara Bailus , Brian Kennedy , Lisa Ellerby , Stanislav Moroz , Ashley Loureiro , Pioneer Grant Fund , Department Of Neurology , National Institutes Of Health , Other Buck Institute , Buck Institute Doublex Fellowship , Icahn School Of Medicine At Mount Sinai , Technical University In Darmstadt , Buck Institute Ellerby ,

A new predictive model helps identify those at risk for severe COVID-19

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Researchers at the Buck Institute analyzed data from the COVID-19 Symptom Tracker app used by 3 million people in the United Kingdom, adding the use of immunosuppressant medication, use of a mobility aid, shortness of breath, fever, and fatigue to the list of symptoms and comorbidities that increase the risk for severe COVID-19. Results are published in the
Even though there are established risk factors for severe COVID-19 there are no good predictors that enable healthcare providers, or even those who have tested positive, to assess who should seek advanced medical care, says Buck Institute Associate Professor David Furman, PhD, the senior scientist who led the study. We are glad to add to the efforts underway around the world to determine how to best care for those infected by the coronavirus. ....

United Kingdom , City Of , Kari Nadeau , Eric Verdin , Dina Radenkovic , Kevin Perez , Yingxiang Huang , King College London , Buck Institute Associate Professor David Furman , Buck Institute , Other Buck Institute , Journal Of Medical Internet Research , Stanford University , Medical Internet , Seeking Treatment , Modeling Predictive Age Dependent , Independent Symptoms , College London , Palo Alto , Medicine Health , Infectious Emerging Diseases , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , காரி நாடிெஓ , எரிக் வெர்டின் , கெவின் பெரெஸ் ,