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New Method Shows TCR's Discriminatory Power is Imperfect

Scientists at the University of Oxford, U.K., use a precise new surface plasmon resonance method to measure very low affinities of T cell receptor binding to self and non-self peptides presented on MHC to show that TCRs are not prefect in their ability to distinguish between healthy and infected cells, as was earlier believed. These new results open new possibilities for treating autoimmune diseases and cancer. ....

Johannes Pettmann , Omer Dushek , Anna Huhn , Radcliffe Department Of Medicine , University Of Oxford , Sir William Dunn School Of Pathology , Senior Research Fellow In Basic Biomedical Sciences , Kennedy Institute , Sir William Dunn School , Radcliffe Department , Enas Abu Shah , Senior Research Fellow , Basic Biomedical Sciences , Wellcome Trust , ராட்க்ளிஃப் துறை ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , ஐயா வில்லியம் டன் பள்ளி ஆஃப் நோயியல் , கெந்நெடீ நிறுவனம் , ஐயா வில்லியம் டன் பள்ளி , ராட்க்ளிஃப் துறை , மூத்தவர் ஆராய்ச்சி சக , அடிப்படை உயிர் மருத்துவ அறிவியல் , வெல்கம் நம்பிக்கை ,

Immune cells imperfect at distinguishing between friend and foe, study suggests

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When it comes to distinguishing a healthy cell from an infected one that needs to be destroyed, the immune system s killer T cells sometimes make mistakes.
This discovery, described today in
eLife, upends a long-held belief among scientists that T cells were nearly perfect at discriminating friend from foe. The results may point to new ways to treat autoimmune diseases that cause the immune system to attack the body, or lead to improvements in cutting-edge cancer treatments.
It is widely believed that T cells can discriminate perfectly between infected cells and healthy ones based on how tightly they are able to bind to molecules called antigens on the surface of each. They bind tightly to antigens derived from viruses or bacteria, but less tightly to our own antigens on normal cells. But recent studies by scientists looking at autoimmune diseases suggest that T cells can attack otherwise normal cells if they express unusually large numbers of our own ant ....

United Kingdom , Johannes Pettmann , Omer Dushek , Emily Packer , Anna Huhn , University Of Oxford , Alice Wallenberg Foundation , Sir William Dunn School Of Pathology , Senior Research Fellow In Basic Biomedical Sciences , Times Higher Education World University Rankings , Radcliffe Department Of Medicine , Oxford University Innovation , Max Planck Society , Oxford University , Kennedy Institute , Howard Hughes Medical Institute , Sir William Dunn School , Radcliffe Department , Enas Abu Shah , Postdoctoral Fellow , Associate Professor , Senior Research Fellow , Basic Biomedical Sciences , Wellcome Trust , Media Relations Manager , Systems Biology ,

Johns Hopkins University: Molecular Alteration May Be Cause — Not Consequence — of Heart Failure

Johns Hopkins University: Molecular Alteration May Be Cause — Not Consequence — of Heart Failure
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United States , Mark Anderson , Natasha Zachara , Priya Umapathi , Centers For Disease , Johns Hopkins University School Of Medicine , Johns Hopkins Medicine , Disease Control , Johns Hopkins University School , O Linkedn Acetylglucosamine , Basic Biomedical Sciences , ஒன்றுபட்டது மாநிலங்களில் , குறி ஆண்டர்சன் , மையங்கள் க்கு நோய் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஜான்ஸ் ஹாப்கின்ஸ் மருந்து , நோய் கட்டுப்பாடு , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி , அடிப்படை உயிர் மருத்துவ அறிவியல் ,

Molecular alteration may be cause -- not consequence -- of heart failure

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Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
Their research found that elevated levels of O-GlcNAc made mice more prone to heart failure, but lowering levels of O-GlcNAc restored the animals risk of death and heart function to normal. Together, the investigators say, the new findings, described online in the April 27th issue of the journal ....

United States , National Taiwan University , T Ai Pei , Natasha Zachara , Priya Umapathi , C Conover Talbot Jr , Jonathan Granger , Johns Hopkins , Olurotimi Mesubi , Qinchuan Wang , Elizabeth Luczak , Neha Abrol , Liliana Florea , Oscar Reyes Gaido , Mark Anderson , Chi Wei , Gerald Hart , Partha Banerjee , Yuejin Wu , Technology Taiwan , Centers For Disease , National Institutes Of Health , Johns Hopkins University School Of Medicine , American Heart Association Collaborative Science Award , University Of Georgia , Ministry Of Science ,

Multi-level social organization and nest-drifting behaviour in a eusocial insect | Proceedings of the Royal Society B: Biological Sciences

Multi-level social organization and nest-drifting behaviour in a eusocial insect | Proceedings of the Royal Society B: Biological Sciences
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