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Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
Their research found that elevated levels of O-GlcNAc made mice more prone to heart failure, but lowering levels of O-GlcNAc restored the animals risk of death and heart function to normal. Together, the investigators say, the new findings, described online in the April 27th issue of the journal ....

United States , National Taiwan University , T Ai Pei , Natasha Zachara , Priya Umapathi , C Conover Talbot Jr , Jonathan Granger , Johns Hopkins , Olurotimi Mesubi , Qinchuan Wang , Elizabeth Luczak , Neha Abrol , Liliana Florea , Oscar Reyes Gaido , Mark Anderson , Chi Wei , Gerald Hart , Partha Banerjee , Yuejin Wu , Technology Taiwan , Centers For Disease , National Institutes Of Health , Johns Hopkins University School Of Medicine , American Heart Association Collaborative Science Award , University Of Georgia , Ministry Of Science ,