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Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain. ....

United States , Lynne Xu , Meiyan Wang , Edward Streim , Shashank Coorapati , Leonardo Andrade , Sarah Parylak , Sammy Weiser Novak , Iryna Gallina , Cristian Quintero , John Adler , April Williams , Jingting Yu , Sarah Fernandes , Maxim Shokhirev , Monisha Saxena , Annettec Merle Smith , Elsa Molina , Salk Institute , National Institutes Of Health , Research On Age , National Eye Institute , Milky Way Foundation , Paulg Allen Frontiers Group Grant , Chapman Foundation , Waitt Foundation ,

Mitochondrial DNA Dysfunction Points to Potential Therapeutic Targets against Inflammation

Mitochondrial DNA Dysfunction Points to Potential Therapeutic Targets against Inflammation
genengnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from genengnews.com Daily Mail and Mail on Sunday newspapers.

San Diego , United States , Audrey Geisel , Gerald Shadel , Laura Newman , University Of California , University Of Virginia , San Diego Nathan Shock Center , Nature Cell Biology , Basic Biology , Audrey Geisel Chair , Biomedical Science , Uri Manor , Waitt Advanced Biophotonics Core ,

Faulty DNA disposal system causes inflammatio

<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>
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Audrey Geisel , Joshua Chevez , Sagnika Ghosh , Matthew Donnelly , Nimesha Tadepalle , Jonas Salk , Gladys Rojas , Gerald Shadel , Laura Newman , Ricardo Rodriguez Enriquez , Danielle Grotjahn , Michaela Medina , Sammy Weiser Novak , Cara Schiavon , Ian Lemersal , Salk Institute , San Diego Nathan Shock Center , Jolla Institute For Immunology , Yale University School Of Medicine Center , Waitt Foundation , Initiative In Brain Health , Salk Pioneer Fund Postdoctoral Scholar Award , National Science Foundation Neuronex Award , Chan Zuckerberg Initiative Imaging Scientist Award , University Of Virginia , Scripps Research Institute ,

Inflammation Linked to Faulty DNA Disposal System

Inflammation Linked to Faulty DNA Disposal System
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Laura Newman , Cara Schiavon , Matthew Donnelly , Audrey Geisel , Ian Lemersal , Sammy Weiser Novak , Michaela Medina , Nimesha Tadepalle , Ricardo Rodriguez Enriquez , Jonas Salk , Gladys Rojas , Danielle Grotjahn , Sagnika Ghosh , Joshua Chevez , Gerald Shadel , Scripps Research Institute , Jolla Institute For Immunology , Initiative In Brain Health , University Of Victoria , University Of Virginia , National Institutes Of Health , Canada Research , Salk Pioneer Fund Postdoctoral Scholar Award , San Diego Nathan Shock Center , Salk Institute For Biological , Yale University School Of Medicine Center ,

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy. ....

Gerald Shadel , Ricardo Rodriguez Enriquez , Sagnika Ghosh , Michaela Medina , Gladys Rojas , Laura Newman , Joshua Chevez , Nimesha Tadepalle , Danielle Grotjahn , Audrey Geisel , Cara Schiavon , Sammy Weiser Novak , Matthew Donnelly , Ian Lemersal , Waitt Foundation , Scripps Research Institute , National Institutes Of Health , Salk Pioneer Fund Postdoctoral Scholar Award , Canada Research , National Science Foundation Neuronex Award , San Diego Nathan Shock Center , Initiative In Brain Health , Salk Institute , University Of Victoria , Yale University School Of Medicine Center , Jolla Institute For Immunology ,