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Discovery: Faulty DNA Disposal System Linked to Inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where i ....

Nimesha Tadepalle , Ricardo Rodriguez Enriquez , Matthew Donnelly , Joshua Chevez , Sagnika Ghosh , Ian Lemersal , Michaela Medina , Laura Newman , Sammy Weiser Novak , Gladys Rojas , Danielle Grotjahn , Cara Schiavon , National Science Foundation Neuronex Award , Salk Pioneer Fund Postdoctoral Scholar Award , University Of Virginia , Waitt Foundation , University Of Victoria , Scripps Research Institute , Chan Zuckerberg Initiative Imaging Scientist Award , Canada Research , National Institutes Of Health , Jolla Institute For Immunology , Yale University School Of Medicine Center , Goeddel Family Technology Sandbox , Salk Institute , Initiative In Brain Health ,

Faulty DNA disposal system causes inflammatio

<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>
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Audrey Geisel , Joshua Chevez , Sagnika Ghosh , Matthew Donnelly , Nimesha Tadepalle , Jonas Salk , Gladys Rojas , Gerald Shadel , Laura Newman , Ricardo Rodriguez Enriquez , Danielle Grotjahn , Michaela Medina , Sammy Weiser Novak , Cara Schiavon , Ian Lemersal , Salk Institute , San Diego Nathan Shock Center , Jolla Institute For Immunology , Yale University School Of Medicine Center , Waitt Foundation , Initiative In Brain Health , Salk Pioneer Fund Postdoctoral Scholar Award , National Science Foundation Neuronex Award , Chan Zuckerberg Initiative Imaging Scientist Award , University Of Virginia , Scripps Research Institute ,

Inflammation Linked to Faulty DNA Disposal System

Inflammation Linked to Faulty DNA Disposal System
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Laura Newman , Cara Schiavon , Matthew Donnelly , Audrey Geisel , Ian Lemersal , Sammy Weiser Novak , Michaela Medina , Nimesha Tadepalle , Ricardo Rodriguez Enriquez , Jonas Salk , Gladys Rojas , Danielle Grotjahn , Sagnika Ghosh , Joshua Chevez , Gerald Shadel , Scripps Research Institute , Jolla Institute For Immunology , Initiative In Brain Health , University Of Victoria , University Of Virginia , National Institutes Of Health , Canada Research , Salk Pioneer Fund Postdoctoral Scholar Award , San Diego Nathan Shock Center , Salk Institute For Biological , Yale University School Of Medicine Center ,

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy. ....

Gerald Shadel , Ricardo Rodriguez Enriquez , Sagnika Ghosh , Michaela Medina , Gladys Rojas , Laura Newman , Joshua Chevez , Nimesha Tadepalle , Danielle Grotjahn , Audrey Geisel , Cara Schiavon , Sammy Weiser Novak , Matthew Donnelly , Ian Lemersal , Waitt Foundation , Scripps Research Institute , National Institutes Of Health , Salk Pioneer Fund Postdoctoral Scholar Award , Canada Research , National Science Foundation Neuronex Award , San Diego Nathan Shock Center , Initiative In Brain Health , Salk Institute , University Of Victoria , Yale University School Of Medicine Center , Jolla Institute For Immunology ,

Faulty DNA disposal system causes inflammation

Faulty DNA disposal system causes inflammation
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Ricardo Rodriguez Enriquez , Gerald Shadel , Audrey Geisel , Laura Newman , Michaela Medina , Danielle Grotjahn , Matthew Donnelly , Joshua Chevez , Sammy Weiser Novak , Cara Schiavon , Ian Lemersal , Sagnika Ghosh , Nimesha Tadepalle , Gladys Rojas , Salk Pioneer Fund Postdoctoral Scholar Award , Chan Zuckerberg Initiative Imaging Scientist Award , Yale University School Of Medicine Center , National Institutes Of Health , National Science Foundation Neuronex Award , Waitt Foundation , Scripps Research Institute , University Of Victoria , University Of Virginia , Jolla Institute For Immunology , Canada Research , Initiative In Brain Health ,