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Re-activating a compromised immune system to fight sepsis

Failure of the immune system during blood poisoning (sepsis) can be reversed by a specific sugar. ....

The Netherlands , Henk Stunnenberg , Mihai Netea , Radboud University , Medical News ,

Vaccine boosts innate immunity in people with dormant immune cells, finds study

Vaccine boosts innate immunity in people with dormant immune cells, finds study
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Christoph Bock Cemm Medical University Of Vienna , Mihai Netea Radboud University Medical Center , Mihai Netea , Radboud University Medical Center , Christoph Bock ,

Vaccine boosts innate immunity in people with

<p><strong>Bacillus Calmette-Gu&eacute;rin (BCG) is one of the world&rsquo;s oldest and most widely used vaccines. It was developed in the early 20<sup>th</sup> century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity. A new study led by Christoph Bock and Mihai Netea found that epigenetic cell states predict whether or not an individual profits from the &ldquo;wake-up call&rdquo; to the innate immune system that is provided by the BCG vaccine. This discovery contributes to the development of future therapeutics that induce protective trained immunity.</strong></p>
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United States , Christoph Bock , Erwin Schr , Mihai Netea , Stefan Bernhardt , Netherlands Royal Academy Of Sciences , Cemm Research Center , University Of Vienna , Christoph Bock Cemm Medical University Of Vienna , Radboud University Medical Center , European Research Council , Mihai Netea Radboud University Medical Center , Department Of Internal Medicine , Prize Of The Austrian Academy Sciences , Research Center , Austrian Academy Of Sciences , European Union Horizon , European Lab For , Infectious Diseases Society Of America , Netherlands Organization For Scientific Research , Austrian Science Fund Special Research Area , Human Cell Atlas Organizing Committee , Method Of Research , Pr Communications , Curie Actions Individual Fellowship , European Union ,