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The rapidly evolving monkeypox epidemic: A call to action to leave no one behind

Author summary Within 5 months, an emerging human monkeypox virus (MPXV) pandemic has caused >65,000 cases, leading the World Health Organization to declare it a public health emergency of international concern (PHEIC). Applying former United States Secretary of Defense Donald Rumsfeld’s idiom, we reflect upon the “known knowns,” “known unknowns,” and “unknown unknowns” to improve prevention and treatment for this and future pandemics. ....

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Versatile coronavirus antibody may be starting point for broader-acting vaccines


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LA JOLLA, CA Even before the COVID-19 pandemic, most people in the United States already had been sick with a coronavirus, albeit a far less dangerous one. That s because at least four coronaviruses in the same general family as SARS-CoV-2 cause the benign yet annoying illness known as the common cold.
In a new study that appears in
Nature Communications, scientists from Scripps Research investigated how the immune system s previous exposure to cold-causing coronaviruses impact immune response to COVID-19. In doing so, they discovered one cross-reactive coronavirus antibody that s triggered during a COVID-19 infection.
The findings will help in the pursuit of a vaccine or antibody treatment that works against most or all coronaviruses, says senior author Raiees Andrabi, PhD, an investigator in the Department of Immunology and Microbiology. ....

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