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Virulent Newcastle Disease Viruses Circulating in Ethiopia


↓ cleavage residues indicate that the NDV isolates correspond to mesogenic/velogenic pathotypes.
Figure 2 Deduced amino acid sequence alignment of F gene sequences of NDV strains isolated from Ethiopia. Names of strains are shown on the left-hand side of the figure. Identification with the reference La Sota (genotype II) vaccine strains is indicated by dots. They indicate the cleavage site of the deduced aa sequence of the F gene. X indicates an ambiguous aa sequence.
Abbreviations: Eth, Ethiopia; Chk, chicken.
Genetic Distance
The Ethiopian NDV isolates have a within-group genetic distance of 10.16% and a between-group genetic distance of 25.1% (Table 2). These isolates are grouped for ease of presentation as published by authors: group1 (sequences characterized in this study from the central part of the country), group 2 from the central part of Ethiopia, ....

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Punicalagin may be a potent drug for rheumatoid arthritis


1
1Department of Nephrology, Kidney and Urology Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, ShenZhen, Guandong, People’s Republic of China;
2Department of Rheumatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guandong, People’s Republic of China;
3Department of Rheumatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guandong, People’s Republic of China
These authors contributed equally to this work
Background: The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural polyphenol extracted in pomegranate juice, which possesses antioxidant, anti-inflammatory and anti-tumor properties suggesting it may be a potent drug for RA therapy. However, there is paucity of information on its effect in RA. ....

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