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How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

Benjamin youngbloodJude department of immunologyJude children research hospitalJude childrenResearch hospitalJude department

Goldilocks binding strength determines anti-cancer T-cell efficacy and fate

Findings showed that how tight a parental T cell binds to a cancer-related protein determines whether its offspring will become functional anti-cancer effector cells or dysfunctional exhausted T cells.

Benjamin youngbloodJude department of immunologyJude department

Goldilocks binding strength determines efficacy and fate of anticancer T cells

Goldilocks binding strength determines efficacy and fate of anticancer T cells
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Goldilocks Binding Strength Dictates T-cell Cancer Battle Outcome

Goldilocks Binding Strength Dictates T-cell Cancer Battle Outcome
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Mohamed nadhir djekidelDietmar zehnPartha chowdhuryShannon boiXueyan liuBenjamin youngbloodYongqiang fengUniversity of tennessee health science centerCollege of graduate health sciencesJude children research hospitalJude department of immunologyNational institutes of healthUniversity of new orleansTechnical university of munichJude childrenResearch hospital

Scientists find Goldilocks binding strength determines anti-cancer T-cell efficacy and fate

Scientists find Goldilocks binding strength determines anti-cancer T-cell efficacy and fate
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Benjamin youngbloodJude children research hospitalJude department of immunologyNature immunologyJude childrenResearch hospitalJude departmentXin lan