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JSR : Crown Bioscience Enters Global Agreement with Shanghai Model Organism Center

Crown Bioscience, a JSR Life Sciences company, this time announces the completion of a global collaboration agreement with the Shanghai Model Organism Center . This agreement extends. ....

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Mice Model Market Worth $2.2 billion | MarketsandMarkets

Mice Model Market Worth $2.2 billion | MarketsandMarkets
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United States , Asia Pacific , Aashish Mehra , Nuerocrine Biosciences , Neurocrine Biosciences , Shanghai Model Organisms Center Inc , Market Development , Vivo Bio Tech Ltd , Model Type Service , Product Development Innovation , Aragen Life Sciences India , Ozgene Pty Ltd , Research Insights , Contract Research Organization Services Market , Services France , National Cancer Institute , Laboratories Co Ltd , Corporation Japan , Taconic Biosciences Inc , Model Market , Model Market Scope , Size Available , Competitive Landscape , Growth Factors , Therapeutic Area , Latin America ,

An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption

Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport oxygen over a long range, its physiological roles outside erythrocytes are largely elusive1,2. Here we found that chondrocytes produced massive amounts of haemoglobin to form eosin-positive bodies in their cytoplasm. The haemoglobin body (Hedy) is a membraneless condensate characterized by phase separation. Production of haemoglobin in chondrocytes is controlled by hypoxia and is dependent on KLF1 rather than the HIF1/2α pathway. Deletion of haemoglobin in chondrocytes leads to Hedy loss along with severe hypoxia, enhanced glycolysis and extensive cell death in the centre of cartilaginous tissue, which is attributed to the loss of the Hedy-controlled oxygen supply under hypoxic conditions. These results demonstrate an extra-erythrocyte role of haemoglobin in chondrocytes, and uncover a heretofore unrecognized mechanism in which chondrocytes survive a hypoxic environment through Hedy. Haem ....

United States , Leica Biosystems , Perkin Elmer , Leica Microsystems , Sakura Finetechnical , Trizol Invitrogen , Agilent Bioanalyzer , Jena Bioscience , M Nacl Chinese Medicine Group Chemical Agent , Fourth Military Medical University , Autocuts Zhenjiang Lehua Technology , Camera Andor Technology , Bio Rad Image Lab , Department Of Pathology Xijing Hospital , Shanghai Biotechnology Corporation , Agilent Technologies , Sysmex Corporation , Shanghai Model Organisms Center , Genomics Institute , Proteome Discoverer Software , M Kcl Chinese Medicine Group Chemical Agent , Research Ethics Board Of The Xijing Hospital , Thermo Fisher , Cell Signaling Technology , Sigma Aldrich , Jackson Labs ,

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice
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United States , United Kingdom , South Africa , A Hong Kong , Zejun Li , Promega Glomax , Co Ltd , Second Military Medical University , National Natural Science Foundation Of China , Shanghai Pujiang Program , Reagent Program , Shanghai Model Organisms Center Inc , Year Grand Program On Key Infectious Disease , Sage Creation Science Co Ltd , Shanghai Public Health Clinical Center , Zymo Research , Technology Commission , Middle East , Expasy Molecular Server , Institutional Animal Care , Use Committee , Shanghai Jihui , Shanghai Model Organisms Center , American Type Culture Collection , Sino Biological , Protein Deglycosylation Mix ,

China greenlights three sci-tech innovation IPOs

BEIJING, Nov. 6 (Xinhua) China securities regulator has approved three companies initial public offerings (IPOs) on the science and technology innovation boa ....

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