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An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption

Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport oxygen over a long range, its physiological roles outside erythrocytes are largely elusive1,2. Here we found that chondrocytes produced massive amounts of haemoglobin to form eosin-positive bodies in their cytoplasm. The haemoglobin body (Hedy) is a membraneless condensate characterized by phase separation. Production of haemoglobin in chondrocytes is controlled by hypoxia and is dependent on KLF1 rather than the HIF1/2α pathway. Deletion of haemoglobin in chondrocytes leads to Hedy loss along with severe hypoxia, enhanced glycolysis and extensive cell death in the centre of cartilaginous tissue, which is attributed to the loss of the Hedy-controlled oxygen supply under hypoxic conditions. These results demonstrate an extra-erythrocyte role of haemoglobin in chondrocytes, and uncover a heretofore unrecognized mechanism in which chondrocytes survive a hypoxic environment through Hedy. Haem ....

United States , Leica Biosystems , Perkin Elmer , Leica Microsystems , Sakura Finetechnical , Trizol Invitrogen , Agilent Bioanalyzer , Jena Bioscience , M Nacl Chinese Medicine Group Chemical Agent , Fourth Military Medical University , Autocuts Zhenjiang Lehua Technology , Camera Andor Technology , Bio Rad Image Lab , Department Of Pathology Xijing Hospital , Shanghai Biotechnology Corporation , Agilent Technologies , Sysmex Corporation , Shanghai Model Organisms Center , Genomics Institute , Proteome Discoverer Software , M Kcl Chinese Medicine Group Chemical Agent , Research Ethics Board Of The Xijing Hospital , Thermo Fisher , Cell Signaling Technology , Sigma Aldrich , Jackson Labs ,

Slide Stainers Market to Witness Robust Expansion throughout the Forecast 2018-2026

Slide Stainers Market to Witness Robust Expansion throughout the Forecast 2018-2026
Slide Stainers Market report includes market status and forecast of global and major regions, with introduction of vendors, regions, product types and end industries; and this report counts product types and end industries in global and major regions
BriefingWire.com, 4/09/2021 -
Global slide stainers market was valued US$ 2.68 Bn in 2017 andis expected to reach US$ 6.1 Bn by 2026, at a CAGR of 10.83 % during a forecast period.
Stain is a substance used to give color to tissues & cells and to facilitate microscopic study & identification. Slide stainers automate the staining of prepared cytology & histology tissue samples by diffusing tints into the samples through surface adsorption, direct staining, indirect staining, and mordant staining. ....

United States , Sakura Finetechnical , Agilent Technologies Inc , Biotechnology Companies , Roche Ltd , Academic Research Institutes , Hospitals Diagnostic Centers , Data Company Inc , Merck Group , Danaher Corporation , Stainers Market , Witness Robust Expansion , Agilent Technologies , Biocare Medical , General Data Company Inc , Hardy Diagnostics , Thermo Fisher , Global Slide Stainers Market , Slide Stainers Market , End User , For Report Description , ஒன்றுபட்டது மாநிலங்களில் , உயிரி தொழில்நுட்பவியல் நிறுவனங்கள் , ரோச் லிமிடெட் , மருத்துவமனைகள் கண்டறியும் மையங்கள் , தகவல்கள் நிறுவனம் இன்க் ,