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New Contender Joins Territory's Promising Energy Sector

Eva LawlerChief Minister of the Northern TerritoryMark MonaghanMinister for MiningMedia ReleaseNew Player enters Territory's highly prospective Energy

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively1–6. Despite the essential roles of these lipids, the mechanisms that enable the cellular uptake of choline and ethanolamine remain unknown. Here we show that the protein encoded by FLVCR1, whose mutation leads to the neurodegenerative syndrome posterior column ataxia and retinitis pigmentosa7–9, transports extracellular choline and ethanolamine into cells for phosphorylation by downstream kinases to initiate the Kennedy pathway. Structures of FLVCR1 in the presence of choline and ethanolamine reveal that both metabolites bind to a common binding site comprising aromatic and polar residues. Despite binding to a common site, FLVCR1 interacts in different ways with the larger quaternary amine of choline in and with the primary amine of ethanolamine. Structure-guided mutagenesis ident

Whitmer signs bills to remove authority from Environmental Rules Review Committee

Governor Gretchen Whitmer signed three bills on Wednesday that her office said will remove authority from the Environmental Rules Review Committee.

Meet The Nigerian Woman Appointed As Special Representative By The UN (Photo)

Michigan rolls out new water filter requirements for schools

All schools and child care centers will be required to implement new rules designed to provide safe drinking water for children, including water filters that reduce lead content.