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The Role of Ceramics in the Aerospace Industry azom.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from azom.com Daily Mail and Mail on Sunday newspapers.
Zinc-based batteries offer a sustainable, high-performance alternative for renewable energy storage, with recent advances tackling traditional limitations. ....
What is a Graphene Field Effect Transistor? azonano.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from azonano.com Daily Mail and Mail on Sunday newspapers.
The use of flow chemistry to generate compound libraries for screening against a biological target enables faster exploration of potential drug candidates, accelerating early drug discovery projects. Click to read more. ....
Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively1–6. Despite the essential roles of these lipids, the mechanisms that enable the cellular uptake of choline and ethanolamine remain unknown. Here we show that the protein encoded by FLVCR1, whose mutation leads to the neurodegenerative syndrome posterior column ataxia and retinitis pigmentosa7–9, transports extracellular choline and ethanolamine into cells for phosphorylation by downstream kinases to initiate the Kennedy pathway. Structures of FLVCR1 in the presence of choline and ethanolamine reveal that both metabolites bind to a common binding site comprising aromatic and polar residues. Despite binding to a common site, FLVCR1 interacts in different ways with the larger quaternary amine of choline in and with the primary amine of ethanolamine. Structure-guided mutagenesis ident ....