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Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study

Objective To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within the recommended schedule) against post-covid-19 condition (PCC).

Design Population based cohort study.

Setting Swedish Covid-19 Investigation for Future Insights a Population Epidemiology Approach using Register Linkage (SCIFI-PEARL) project, a register based cohort study in Sweden.

Participants All adults (≥18 years) with covid-19 first registered between 27 December 2020 and 9 February 2022 (n=589 722) in the two largest regions of Sweden. Individuals were followed from a first infection until death, emigration, vaccination, reinfection, a PCC diagnosis (ICD-10 diagnosis code U09.9), or end of follow-up (30 November 2022), whichever came first. Individuals who had received at least one dose of a covid-19 vaccine before infection were considered vaccinated.

Main outcome measure The primary outcome was a clinical diagnosis of PCC. Vac ....

United States , Vastra Gotalands Lan , Bristol Myers Squibb , Lisa Lundberg Morris , Yiyi Xu , Susannah Leach , King Gustaf , Maria Bygdell , Scilifelab Knut , S Janssen Johnson , Huiqi Li , Fredrik Nyberg , Jari Martikainen , Magnus Gissl , Ailiana Santosa , Swedish Research Council For Environment , Longitudinal Integrated Database For Health Insurance , National Board Of Health , Alice Wallenberg Foundation , Rr Core Team , Swedish Social Insurance Agency , R Statistical Software , Queen Victoria Foundation , Research Agreement , Agricultural Sciences , National Patient Register ,

Comparative effectiveness of heterologous third dose vaccine schedules against severe covid-19 during omicron predominance in Nordic countries: population based cohort analyses

Objective To investigate the comparative vaccine effectiveness of heterologous booster schedules (ie, three vaccine doses) compared with primary schedules (two vaccine doses) and with homologous mRNA vaccine booster schedules (three vaccine doses) during a period of omicron predominance.

Design Population based cohort analyses.

Setting Denmark, Finland, Norway, and Sweden, 27 December 2020 to 31 December 2022.

Participants All adults aged ≥18 years who had received at least a primary vaccination schedule of AZD1222 (Oxford-AstraZeneca) or monovalent SARS-CoV-2 wild type (ancestral) strain based mRNA vaccines BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna), in any combination.

Main outcome measures The main outcome measure was country combined risks of covid-19 related hospital admission and death with covid-19 and additional outcomes of covid-19 related admission to an intensive care unit and SARS-CoV-2 infection. During a period of omicron predominance, ....

United Kingdom , Karolinska Institutet , Morten Andersen , Lars Christian Lund , Ulrike Baum , Coronavac Sinovac , Anders Hviid , Jostein Starrfelt , Eero Poukka , Jesper Hallas , Nicklas Pihlstr , Hinta Meijerink , S Janssen Johnson , Jesper Kj , Christian Holm Hansen , Mathijs Goossens , Catherine Cohet , Rickard Ljung , Emilia Myrup Thiesson , Mia Aakj , Pharmacovigilance Research Centre , Menarini Pharmaceuticals , Novo Nordisk , Sanofi Aventis , University Of Copenhagen , Finnish Medical Foundation ,