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Bidirectional Link Identified Between Depression, Inflammatory Joint Disease

This analysis may require further research to determine whether other treatment-resistant depression or severe depression definitions are specifically associated with inflammatory joint disease. ....

Philip Brenner , Karolinska University Hospital Solna , Longitudinal Integrated Database For Health Insurance , Swedish National Patient Register , Total Population Register , Prescribed Drug Register , Longitudinal Integrated Database , Health Insurance , Labour Market Studies ,

ADHD Drugs Linked to Cardiovascular Disease

Service users taking drugs to treat ADHD may be at increased risk for hypertension and arterial disease. ....

Karolinska Institutet , Yale Zhang , Longitudinal Integrated Database For Health Insurance , National Inpatient Register , Swedish Prescribed Drug Register , Longitudinal Integrated Database , Health Insurance , Labour Market , Swedish Cause , Death Register , Hyperactivity Disorder Medications , Long Term Risk ,

Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study

Objective To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within the recommended schedule) against post-covid-19 condition (PCC).

Design Population based cohort study.

Setting Swedish Covid-19 Investigation for Future Insights a Population Epidemiology Approach using Register Linkage (SCIFI-PEARL) project, a register based cohort study in Sweden.

Participants All adults (≥18 years) with covid-19 first registered between 27 December 2020 and 9 February 2022 (n=589 722) in the two largest regions of Sweden. Individuals were followed from a first infection until death, emigration, vaccination, reinfection, a PCC diagnosis (ICD-10 diagnosis code U09.9), or end of follow-up (30 November 2022), whichever came first. Individuals who had received at least one dose of a covid-19 vaccine before infection were considered vaccinated.

Main outcome measure The primary outcome was a clinical diagnosis of PCC. Vac ....

United States , Vastra Gotalands Lan , Bristol Myers Squibb , Lisa Lundberg Morris , Yiyi Xu , Susannah Leach , King Gustaf , Maria Bygdell , Scilifelab Knut , S Janssen Johnson , Huiqi Li , Fredrik Nyberg , Jari Martikainen , Magnus Gissl , Ailiana Santosa , Swedish Research Council For Environment , Longitudinal Integrated Database For Health Insurance , National Board Of Health , Alice Wallenberg Foundation , Rr Core Team , Swedish Social Insurance Agency , R Statistical Software , Queen Victoria Foundation , Research Agreement , Agricultural Sciences , National Patient Register ,

Population frailty trends by education and income levels over a period of 30 years: findings from Swedish registry data

Background Frailty is an age-related health condition affecting an estimated 18% of older adults in Europe and past evidence has shown a relationship between socioeconomic factors and frailty. We examined population frailty trends and the association between frailty and 5-year mortality by education tertiles and income quartiles at ages 75, 85 and 95 in Swedish registry data.

Methods All Swedish residents born in 1895–1945 and in the Total Population Register from 1990 to 2020 were included. Frailty was assessed with the Hospital Frailty Risk Score (HFRS), which sums 109 weighted International Classification of Diseases (ICD codes), collected from the National Patient Register.

Results Regardless of education and income, frailty increased over time, though the association between frailty and 5-year mortality remained stable. Particularly in earlier birth cohorts, although the highest education and income levels had the highest mean HFRS scores, the lowest education and ....

United States , Eteläuomen Läi , Karolinska Institutet Dnr , National Patient Register , Longitudinal Integrated Database For Health Insurance , Total Population Register , Longitudinal Integrated Database , Health Insurance , Labour Market Studies , Hospital Frailty Risk Score , Rockwood Frailty Index , College Station , General Data Protection Regulation , Karolinska Institutet ,

Sociodemographic factors before MS diagnosis tied to disease severity

Sociodemographic factors before MS diagnosis tied to disease severity
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Karolinska Institute , Longitudinal Integrated Database For Health Insurance , National Patient Register , Health Care Context , Longitudinal Integrated Database , Health Insurance , Labor Market Studies , Expanded Disability Status Scale , Multiple Sclerosis Impact Scale , Premorbid Sociodemographic Status , Multiple Sclerosis Outcomes , Universal Health Care Context ,