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SARS-CoV-2 with Genomic Deletions Escapes an Antibody
Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.
Feb 16, 2021
ABOVE: Merged images illustrate multiple antibodies (green and red) binding to the wildtype SARS-CoV-2 spike protein, which is produced by human cells (DNA in blue, left). In cells (DNA in blue, right) that produce a version of the spike protein with deletions, some antibodies fail to bind (absence of green), while others (red) still attach well.
KEVIN MCCARTHY AND PAUL DUPREX
When SARS-CoV-2, the virus behind the COVID-19 pandemic, first emerged, scientists expected it to evolve slowly because the virus copies its big RNA genome with a polymerase that also corrects errors, thus minimizing the chance for certain types of mutations. This enzyme functionality isn’t present in other RNA viruses such as i ....

South Africa , New York , United States , Rockefeller University , United Kingdom , Paul Duprex , Kevin Mccarthy , Theodora Hatziioannou , Gregory Ippolito , George Georgiou , Jason Lavinder , University Of Pittsburgh Medical Center , World Health Organization , Vaccine Research At Pitt , Global Initiative On Sharing All Influenza Data , University Of Pittsburgh , University Of Texas , Pittsburgh Medical Center , Vaccine Research , Global Initiative , Sharing All Influenza Data , Rxivin December , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ராக்ஃபெல்லர் பல்கலைக்கழகம் , ஒன்றுபட்டது கிஂக்டம் ,