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St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme. ....

Balamurugan Sundaram , Yaqiu Wang , Hee Jin Kim , Rk Subbarao Malireddi , Roman Sarkar , Rajendra Karki , Danielle Ellis , Thirumala Devi Kanneganti , Laura Janke , Nagakannan Pandian , Peter Vogel , National Institutes Of Health , Jude Children Research Hospital , Jude Department Of Immunology , Jude Children , Research Hospital , Co First Author , Jude Department , Innate Immunity , Raghvendra Mall , National Institutes , Ell Death , Inflammatory Disease , Red Blood Cells , Ars Cov 2 , Sickle Cell Disease ,

Promising preclinical cancer therapy harnesses newly discovered cell death pathway

Thirumala-Devi Kanneganti, PhD, St. Jude Department of Immunology, and Rajendra Karki, PhD, St. Jude Immunology, led research that found interactions ....

Bhesh Raj Sharma , Nhat Nguyen , Rajendra Karki , Geoffrey Neale , Parimal Samir , Rk Subbarao Malireddi , Balamurugan Sundaram , Sangjoon Lee , Thirumala Devi Kanneganti , Yaqiu Wang , Peter Vogel , Jude Children Research Hospital , National Institutes Of Health , Drug Administration , Jude Department Of Immunology , Jude Children , Research Hospital , Shelbi Christgen , Lam Nhat Nguyen , Amin Zheng , National Institutes , Published October ,