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First Patient Dosed in STARSTRUCK Study of TLX250 Targeted Radiation Therapy in Combination with Merck Investigational DNA-PK Inhibitor, Peposertib

MELBOURNE, Australia, July 19, 2023 /PRNewswire/ Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company)today announces that the first patient has been dosed in a Phase I study of the Company's investigational targeted radiation therapy, TLX250, in combination with a Merck KGaA, Darmstadt, Germany (Merck) DNA-dependent protein kinase (DNA-PK) inhibitor candidate, peposertib (M3814). The study is being conducted in patients with solid tumours expressing carbonic-anhydrase IX (CAIX), a potential pan-cancer target. STARSTRUCK (ClinicalTrials.gov Identifier: NCT05868174) is a Phase Ib, open label, single-arm, multicentre dose escalation and dose expansion study to evaluate the safety profile, dosing and activity of TLX250 (177Lu-DOTA-girentuximab) in combination with the DNA damage response inhibitor (DDRi) peposertib, which is an inhibitor of DNA-PK. The target population is patients with CAIX-expressing solid tumours that are relapsed or refractory to standard therapies. Up to ....

United States , United Kingdom , Merck Ddri , Nat Lenzo , Kyahn Williamson , Colin Hayward , Genesiscare Murdoch , Health Canada , Telix Pharmaceuticals , Merck Kga , European Union , Merck Kgaa , Australian Therapeutic Goods Administration , Prnewswire Telix Pharmaceuticals Limited , Genesiscare Group Clinical , Drug Administration , Australian Securities Exchange , Corporate Communications , Pharmaceuticals Limited , Professor Nat Lenzo , Genesiscare Group Clinical Director Theranostics , Chief Medical Officer , Telix Pharmaceuticals Limited , July 19 , 023 Prnewswire Telix Pharmaceuticals Limited Asx Tlx , He Company Today Announces That The First Patient Has Been Dosed Ina Phasei Study Of 39s Investigational Targeted Radiation Therapy ,

Telix to Supply Bayer with Illuccix for Global Phase III Prostate Cancer Study

MELBOURNE, Australia, May 8, 2023 /PRNewswire/ Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that it has entered into an agreement with Bayer AG (Bayer) to supply Illuccix (TLX591-CDx, kit for the preparation of gallium Ga 68 gozetotide injection)[1] for the Phase III ARASTEP study (ClinicalTrials.gov Identifier: NCT05794906). This global study is investigating the efficacy of Bayer's androgen receptor inhibitor (ARi) darolutamide plus androgen deprivation therapy (ADT) versus ADT alone in hormone-sensitive prostate cancer, in patients with high-risk biochemical recurrence who have no evidence of metastatic disease by conventional imaging and a positive PSMA-PET/CT[2] at baseline. The study will enrol up to 750 patients across various sites such as in Europe, Japan and the United States. The more sensitive PSMA imaging may identify prostate cancer lesions not detectable by conventional imaging such as computed tomography (CT) scans, magnetic resonan ....

United States , United Kingdom , Bayer Cross , Kyahn Williamson , Colin Hayward , Orion Corporation , European Union , Prnewswire Telix Pharmaceuticals Limited , Corporate Communications , Drug Administration , Australian Securities Exchange , Health Canada , Australian Therapeutic Goods Administration , Telix Pharmaceuticals , Bayer Ag , Pharmaceuticals Limited , Chief Medical Officer , Telix Pharmaceuticals Limited , May 8 , 023 Prnewswire Telix Pharmaceuticals Limited Asx Tlx , He Company Today Announces That It Has Entered Into An Agreement With Bayer Ag To Supply Illuccix Tlx591 Cdx , It For The Preparation Of Gallium Ga 68 Gozetotide Injection 1 Phase Iii Arastep Study Clinicaltrials Gov Identifier Nct05794906 This Global Is Investigating Efficacy Bayer 39s Androgen Receptor Inhibitor Ari Darolutamide Plus Deprivation Therapy Adt Versus Alone In Hormone Sensitive Prostate Cancer , N Patients With High Risk Biochemical Recurrence Who Have No Evidence Of Metastatic Disease By Conventional Imaging Anda Positive Psma Pet Ct 2 At Baseline The Study Will Enrol Up To 750 Across Various Sites Such As In Europe , Apan And The United States More Sensitive Psma Imaging May Identify Prostate Cancer Lesions Not Detectable By Conventional Such As Computed Tomography Ct Scans , Agnetic Resonance Imaging Mri And Bone Scans Telix Chief Medical Officer , R Colin Hayward Stated ,

TLX250-CDx Indication Expansion: Preliminary Data Presented at EANM

OPALESCENCE Phase II feasibility study of TLX250-CDx in patients with triple-negative breast cancer - early results suggest potential to detect carbonic anhydrase IX (CAIX) expression, theranostic potential in this difficult to treat disease. PERTINENCE Early Phase I feasibility study of TLX250-CDx in patients with non-muscle-invasive bladder cancer, a collaboration with ATONCO - early results support translation to first-in-human therapeutic studies with the alpha-emitting radioisotope astatine-211 (211At). Both investigator-initiated studies being undertaken by Dr. Caroline Rousseau at the Institut de Cancerologie de l'Ouest (ICO) in St Herblain (France). Results delivered at the European Association of Nuclear Medicine (EANM) Annual Congress currently taking place in Barcelona, Spain. MELBOURNE, Australia, Oct. 18, 2022 /PRNewswire/ Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company)today announces preliminary data from two separate investigator-initiated studies of TL ....

United States , United Kingdom , Comunidad Autonoma De Cataluna , Jean Francois Chatal , Kyahn Williamson , Colin Hayward , Caroline Rousseau , Telix Pharmaceuticals , Drug Administration , European Association Of Nuclear Medicine , Australian Securities Exchange , Australian Therapeutic Goods Administration , World Cancer Research Fund , Corporate Communications , Telix Pharmaceuticals Limited , Innovation Centre , Health Canada , American Cancer Society , Institut De Cancerologie , European Association , Nuclear Medicine , Annual Congress , Chief Medical Officer , Medical Officer , Breakthrough Therapy , Cancer Research Fund ,