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Telix Pharmaceuticals Limited: First Patient Dosed in Phase III ProstACT GLOBAL Study of Antibody-based Prostate Cancer Therapy Candidate, TLX591

Telix Pharmaceuticals Limited: First Patient Dosed in Phase III ProstACT GLOBAL Study of Antibody-based Prostate Cancer Therapy Candidate, TLX591
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First Patient Dosed in Phase III ProstACT GLOBAL Study of Antibody-based Prostate Cancer Therapy Candidate, TLX591

Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that the first patient has been dosed in the Company's Phase III ProstACT GLOBAL study of its investigational prostate-specific membrane antigen (PSMA) targeting radio-antibody drug conjugate (rADC) therapy, TLX591 (177Lu-rosopatamab tetraxetan). TLX591 is a rADC composed of a high-specificity PSMA-targeting antibody, chelator linker, and cytotoxic lutetium (177Lu) payload. The PSMA-targeted monoclonal antibody (mAb) ap ....

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ProstACT SELECT Study of TLX591 Interim Readout: Positive Results Confirm Safety and Tolerability

The study has achieved its primary objectives, confirming the safety and tolerability profile of TLX591 administered in two doses, two weeks apart in combination with standard of care (SoC) Preliminary activity demonstrates meaningfulPSA[1] reduction; monitoring of patients is ongoing, including for rPFS[2] Findings reinforce the potential advantages of this first-in-class radio-antibody drug conjugate (rADC) investigational therapy, consistent with previous clinical studies of TLX591[3] MELBOURNE, Australia, Oct. 19, 2023 /PRNewswire/ Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company)today announces positive preliminary results from the Phase I ProstACT SELECT study of its rADC therapy candidate TLX591 (Lutetium (177Lu) rosopatamab tetraxetan) for prostate-specific membrane antigen (PSMA) positive metastatic castration-resistant prostate cancer (mCRPC). The purpose of the SELECT study (ClinicalTrials.gov ID: NCT04786847)was to evaluate the utility of PSMA imaging to select ....

New York , United States , United Kingdom , Scottt Tagawa , Nat Lenzo , Colin Hayward , Kyahn Williamson , Corporate Communications , Telix Pharmaceuticals Limited Disclosure Committee , Drug Administration , Prnewswire Telix Pharmaceuticals Limited , European Union , Telix Pharmaceuticals , Australian Therapeutic Goods Administration , Genesiscare Group Clinical , Australian Securities Exchange , Health Canada , Pharmaceuticals Limited , Genesiscare Group Clinical Director Theranostics , Telix Chief Medical Officer , Marketing Authorisation Applications , Telix Pharmaceuticals Limited , The Study Has Achieved Its Primary Objectives , Onfirming The Safety And Tolerability Profile Of Tlx591 Administered In Two Doses , Wo Weeks Apart In Combination With Standard Of Care Soc Preliminary Activity Demonstrates Meaningfulpsa 1 Reduction Monitoring Patients Is Ongoing , Ncluding For Rpfs 2 Findings Reinforce The Potential Advantages Of This First In Class Radio Antibody Drug Conjugate Radc Investigational Therapy ,

ProstACT SELECT Study of TLX591 Interim Readout: Positive Results Confirm Safety and Tolerability

ProstACT SELECT Study of TLX591 Interim Readout: Positive Results Confirm Safety and Tolerability
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Telix Pharmaceuticals Limited: ProstACT SELECT Study of TLX591 Interim Readout: Positive Results Confirm Safety and Tolerability

Telix Pharmaceuticals Limited: ProstACT SELECT Study of TLX591 Interim Readout: Positive Results Confirm Safety and Tolerability
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