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Circulating myeloid-derived MMP8 in stress susceptibility and depression

Psychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of mass cytometry and single-cell RNA sequencing, we performed high-dimensional phenotyping of immune cells in circulation and in the brain and demonstrate that peripheral monocytes are strongly af ....

United States , South Korea , Lookeren Campagne , Brunstein Klomek , J Health Soc , Research Version American Psychiatric Association , Psychiatry Rep , Cancer Biol , Open Sci , Growth Factor Rev , Cell Biol , Structured Clinical Interview , American Psychiatric Association ,

MindBio Therapeutics Ethics Approval for Landmark World First Phase ...

MindBio Therapeutics Ethics Approval for Landmark World First Phase . ....

British Columbia , Justin Hanka , News Network , Mindbio Therapeutics Corp , Centers For Disease , Company Or Mindbio , Clinical Trials Registryone , Microdosing Clinical Trials , Mindbio Therapeutics , Major Depressive , Clinical Trials , New Zealand , Disease Control , Creativitywellnessenergychief Executive Officer , Chief Executive Officer , Psychiatry Rep , Prefer Adherence , Lysergic Acid Diethylamide , Major Depressive Disorder , Note Concerning Forward Looking Statements ,

MindBio Therapeutics Ethics Approval for Landmark World First Phase 2 Clinical Trial of Take-Home LSD-Microdosing for Major Depressive Disorder

MindBio Therapeutics Ethics Approval for Landmark World First Phase 2 Clinical Trial of Take-Home LSD-Microdosing for Major Depressive Disorder
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British Columbia , Justin Hanka , Centers For Disease , Canadian Securities Exchange , Mindbio Therapeutics Corp , Company Or Mindbio , Regulation Service Provider , Neither The Canadian Securities Exchange , Wall Street , Clinical Trials , Microdosing Clinical Trials , Mindbio Therapeutics , Major Depressive , New Zealand , Disease Control , Executive Officer , Chief Executive , Psychiatry Rep , Prefer Adherence , Lysergic Acid Diethylamide , Major Depressive Disorder , Note Concerning Forward Looking Statements ,

How to Treat: Anorexia nervosa in young people

Since the onset of the COVID-19 pandemic, rates of eating disorders, particularly anorexia nervosa, have dramatically increased both in New Zealand and overseas. Young people with anorexia are most likely to present to primary care services. In this article, Hiran Thabrew offers new ideas for supporting this group of young people during the COVID-19 era ....

New Zealand , United States , Le Grange , El Ghoch , Rau Hinengaro , American Psychiatric Association , Victoria University Of Wellington , Rangatahi Smart , Zealand Mental Health , Research Group , Access To Health Services , Zealand College Of Psychiatrists , University Of Auckland , Statistical Manual , Mental Disorders , New Zealand Mental Health , Austn Zj Psychiatry , Medj Aust , Smart Survey , Initial Findings , Victoria University , Gen Psychiatry , Psychiatry Rep , New Zealand College ,

Not much to show for $1.9 billion: New directions in mental health needed

This article highlights new ways of understanding mental illness and explores new treatment strategies, including the use of nutrients in carefully targeted patient groups ....

New Zealand , Nat Genet , Acta Neuropsychiatrica , Nat Neurosci , Disorder Group Of The Psychiatric Genomics Consortium , Mental Health , Pathway Analysis Subgroup Of Psychiatric Genomics Consortium , Ara Oranga , Government Inquiry , Psychiatry Rep , Depressive Disorder Working Group , Disorder Group , Psychiatric Genomics , Pathway Analysis Subgroup , Database Syst Rev , Neurobiological Understanding ,