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Nanobodies inhibit SARS-CoV-2 infection

Date Time
Nanobodies inhibit SARS-CoV-2 infection
Australian researchers have identified neutralising nanobodies that block the SARS-CoV-2 virus from entering cells in preclinical models.
The discovery paves the way for further investigations into nanobody-based treatments for COVID-19.
Visualisation of SARS-CoV-2 virus with nanobodies (purple)
attaching to the virus ‘spike’ protein.
Image: Dr Drew Berry in collaboration with
Associate Professor Wai-Hong Tham
Published in PNAS, the research is part of a consortium-led effort, bringing together the expertise of Australian academic leaders in infectious diseases and antibody therapeutics at WEHI, the Doherty Institute and the Kirby Institute.
At a glance
Researchers have identified nanobodies that effectively blocked the SARS-CoV-2 virus from entering cells in pre-clinical models of COVID-19 infection. ....

Marcel Doerflinger , Alisa Glukhova , Matthew Oneill , Melanieh Dietrich , Amy Adair , Phillip Pymm , Hariprasad Venugopal , Michael Dengler , Marc Pellegrini , James Cooney , Cody Allison , Li Jin Chan , Doherty Institute , Kirby Institute , Research Future Fund , Monash Ramaciotti Centre For Cryo , Hengyi Group , Professor Wai Hong Tham , Associate Professor Wai Hong Tham , Professor Tham , Monash Ramaciotti Centre , Cryo Electron Microscopy , Senior Microscopist , Medical Research Future Fund , Matthewo Neill , Damien Drew ,

Hidden donations highlight 'grave weakness of Australian democracy'

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Federal political parties have received $1.1 billion from hidden donors in a trend towards greater secrecy over two decades, says a new report that warns of dangerous failures in the system meant to expose vested interests.
A handful of dominant players have increased their sway over federal politics by making one-quarter of all donations over the period, led by mining magnate Clive Palmer as well as Liberal and union funds.
Big time political party donor, Clive Palmer.
Credit:
In a damning assessment of the disclosure regime, the not-for-profit Centre for Public Integrity says voters are being denied crucial facts about who has paid for influence with about $3 billion in party income over two decades. ....

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