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Natural immunity to malaria provides clues to potential therapies


Date Time
Natural immunity to malaria provides clues to potential therapies
WEHI researchers have identified how natural human antibodies can block malaria parasites from entering red blood cells, potentially indicating how new protective therapies could be developed against this globally significant disease.
Dr Melanie Dietrich, Li Jin Chan and Associate Professor
Wai-Hong Tham
The research provides greater insight into how antibodies block the entry of Plasmodium vivax malaria parasites into young red blood cells called reticulocytes. It builds on an earlier discovery that the P. vivax latches onto the transferrin receptor 1 (TfR1) to enter cells.
The research, led by Associate Professor Wai-Hong Tham and PhD student Li-Jin Chan from WEHI, alongside Professor Christopher King from Case Western University, US, was published in Nature Communications. ....

Papua New Guinea , Li Jin Chan , Christopher King , Melanie Dietrich , Sebastien Menant , Camila Fran , Ivo Mueller , Nature Communications , National Health , Case Western University , European Research Council , Research Council , Associate Professor Wai Hong Tham , Professor Christopher King , Associate Professor Tham , Professor Tham , Medical Research Council , Jin Chan , Walter And Eliza Hall Institute , European Research Council , Nature Communications , Western University , Papua New Guinea , Research Council , Medical Research , பப்புவா புதியது கினியா ,

Discovery opens new avenues for developing antibody-based therapies for malaria


Discovery opens new avenues for developing antibody-based therapies for malaria
WEHI researchers have identified how natural human antibodies can block malaria parasites from entering red blood cells, potentially indicating how new protective therapies could be developed against this globally significant disease.
The research provides greater insight into how antibodies block the entry of Plasmodium vivax malaria parasites into young red blood cells called reticulocytes. It builds on an earlier discovery that the
P. vivax latches onto the transferrin receptor 1 (TfR1) to enter cells.
The research, led by Associate Professor Wai-Hong Tham and PhD student Li-Jin Chan from WEHI, alongside Professor Christopher King from Case Western University, US, was published in Nature Communications. ....

Papua New Guinea , Christopher King , Li Jin Chan , Ivo Mueller , Emily Henderson , Nature Communications , National Health , Case Western University , European Research Council , Research Council , Associate Professor Wai Hong Tham , Professor Christopher King , Associate Professor Tham , Professor Tham , Medical Research Council , பப்புவா புதியது கினியா , கிறிஸ்டோபர் கிங் , இவோ முல்லர் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , தேசிய ஆரோக்கியம் , வழக்கு மேற்கு பல்கலைக்கழகம் , ஐரோப்பிய ஆராய்ச்சி சபை , ஆராய்ச்சி சபை , இணை ப்ரொஃபெஸர் வாய் ஹாங் தாம் , ப்ரொஃபெஸர் கிறிஸ்டோபர் கிங் ,

Nanobodies inhibit SARS-CoV-2 infection


Date Time
Nanobodies inhibit SARS-CoV-2 infection
Australian researchers have identified neutralising nanobodies that block the SARS-CoV-2 virus from entering cells in preclinical models.
The discovery paves the way for further investigations into nanobody-based treatments for COVID-19.
Visualisation of SARS-CoV-2 virus with nanobodies (purple)
attaching to the virus ‘spike’ protein.
Image: Dr Drew Berry in collaboration with
Associate Professor Wai-Hong Tham
Published in PNAS, the research is part of a consortium-led effort, bringing together the expertise of Australian academic leaders in infectious diseases and antibody therapeutics at WEHI, the Doherty Institute and the Kirby Institute.
At a glance
Researchers have identified nanobodies that effectively blocked the SARS-CoV-2 virus from entering cells in pre-clinical models of COVID-19 infection. ....

Marcel Doerflinger , Alisa Glukhova , Matthew Oneill , Melanieh Dietrich , Amy Adair , Phillip Pymm , Hariprasad Venugopal , Michael Dengler , Marc Pellegrini , James Cooney , Cody Allison , Li Jin Chan , Doherty Institute , Kirby Institute , Research Future Fund , Monash Ramaciotti Centre For Cryo , Hengyi Group , Professor Wai Hong Tham , Associate Professor Wai Hong Tham , Professor Tham , Monash Ramaciotti Centre , Cryo Electron Microscopy , Senior Microscopist , Medical Research Future Fund , Matthewo Neill , Damien Drew ,