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Luxembourg Researchers Find Allergy-Induced Inflammation Combats Brain Tumour Progression

Luxembourg Researchers Find Allergy-Induced Inflammation Combats Brain Tumour Progression
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Markus Ollert , Luxembourg Institute Of Health , Luxembourg Institute , Prof Markus Ollert ,

New study further advances the treatment of chronic pain

Scientists from the Immuno-Pharmacology and Interactomics group at the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. The researchers also developed a synthetic analogue of conolidine, RTI-5152-12, which displays an even greater activity on the receptor. ....

Andy Chevign , Ojas Namjoshi , Martyna Szpakowska , Markus Ollert , Ministry Of Higher Education , Department Of Infection , Nature Communications , Immunity Of The Luxembourg Institute Health , European Commission , Luxembourg National Research Fund , Luxembourg Institute , Drug Discovery , Signal Transduction , Targeted Therapy , Prof Markus Ollert , Higher Education , Cell Biology , Molecular Biology , Medicine Health , அமைச்சகம் ஆஃப் அதிக கல்வி , துறை ஆஃப் தொற்று , இயற்கை தகவல்தொடர்புகள் , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய தரகு , லக்ஸம்பர்க் தேசிய ஆராய்ச்சி நிதி , லக்ஸம்பர்க் நிறுவனம் ,

Research opens alternative therapeutic avenues for treatment of chronic pain

Building on their previous findings, scientists from the Immuno-Pharmacology and Interactomics group at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), a nonprofit research institute, have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. ....

Andy Chevign , Ojas Namjoshi , Martyna Szpakowska , Markus Ollert , Emily Henderson , Ministry Of Higher Education , Department Of Infection , Nature Communications , Immunity Of The Luxembourg Institute Health , European Commission , Luxembourg National Research Fund , Luxembourg Institute , Drug Discovery , Signal Transduction , Targeted Therapy , Prof Markus Ollert , Higher Education , Chronic Pain , Drug Discovery , எமிலி ஹென்டர்சன் , அமைச்சகம் ஆஃப் அதிக கல்வி , துறை ஆஃப் தொற்று , இயற்கை தகவல்தொடர்புகள் , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய தரகு , லக்ஸம்பர்க் தேசிய ஆராய்ச்சி நிதி ,

New Immunotherapy Helps Treat Cat Allergy

New Immunotherapy Helps Treat Cat Allergy
by Angela Mohan on
February 8, 2021 at 3:08 PM
High doses of CpG oligonucleotide helps in successfully modulating the immune system s allergic response to the main cat allergen Fel d 1, inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy, as per researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH).
The researchers analysed the molecular mechanisms underlying this tolerance and proposed a pre-clinical allergen-specific immunotherapy approach to improve the treatment and control of this common type of allergy.
The full study results were published recently in the renowned international journal ....

Markus Ollert , Department Of Infection , Immunity Of The Luxembourg Institute Health , European Academy Of Allergy , Luxembourg Institute , European Academy , Clinical Immunology , Natural Killer , Tumour Necrosis Factor , Prof Markus Ollert , Right Over The Counter Drugs , Seasonal Allergy , Pollen Allergyremedies , Evaluationstay Well This , Specific Adjuvant Molecule , European Academy Of Allergy And Clinical Immunology , Tolerance Promoting Reaction , துறை ஆஃப் தொற்று , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய கலைக்கழகம் ஆஃப் ஒவ்வாமை , லக்ஸம்பர்க் நிறுவனம் , ஐரோப்பிய கலைக்கழகம் , மருத்துவ நோயெதிர்ப்பு , இயற்கை கில்லர் , சரி ஓவர் தி எதிர் மருந்துகள் , பருவகால ஒவ்வாமை ,

Novel immunotherapy approach to treat cat allergy

Credit: Copyright: LIH
Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system s allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy. The researchers analysed the molecular mechanisms underlying this tolerance and proposed a pre-clinical allergen-specific immunotherapy approach to improve the treatment and control of this common type of allergy. The full study results were published recently in the renowned international journal ....

Markus Ollert , Department Of Infection , Immunity Of The Luxembourg Institute Health , European Academy Of Allergy , Luxembourg Institute , European Academy , Clinical Immunology , Natural Killer , Tumour Necrosis Factor , Prof Markus Ollert , துறை ஆஃப் தொற்று , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய கலைக்கழகம் ஆஃப் ஒவ்வாமை , லக்ஸம்பர்க் நிறுவனம் , ஐரோப்பிய கலைக்கழகம் , மருத்துவ நோயெதிர்ப்பு , இயற்கை கில்லர் ,