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New study further advances the treatment of chronic pain

Scientists from the Immuno-Pharmacology and Interactomics group at the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. The researchers also developed a synthetic analogue of conolidine, RTI-5152-12, which displays an even greater activity on the receptor. ....

Andy Chevign , Ojas Namjoshi , Martyna Szpakowska , Markus Ollert , Ministry Of Higher Education , Department Of Infection , Nature Communications , Immunity Of The Luxembourg Institute Health , European Commission , Luxembourg National Research Fund , Luxembourg Institute , Drug Discovery , Signal Transduction , Targeted Therapy , Prof Markus Ollert , Higher Education , Cell Biology , Molecular Biology , Medicine Health , அமைச்சகம் ஆஃப் அதிக கல்வி , துறை ஆஃப் தொற்று , இயற்கை தகவல்தொடர்புகள் , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய தரகு , லக்ஸம்பர்க் தேசிய ஆராய்ச்சி நிதி , லக்ஸம்பர்க் நிறுவனம் ,

Research opens alternative therapeutic avenues for treatment of chronic pain

Building on their previous findings, scientists from the Immuno-Pharmacology and Interactomics group at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), a nonprofit research institute, have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. ....

Andy Chevign , Ojas Namjoshi , Martyna Szpakowska , Markus Ollert , Emily Henderson , Ministry Of Higher Education , Department Of Infection , Nature Communications , Immunity Of The Luxembourg Institute Health , European Commission , Luxembourg National Research Fund , Luxembourg Institute , Drug Discovery , Signal Transduction , Targeted Therapy , Prof Markus Ollert , Higher Education , Chronic Pain , Drug Discovery , எமிலி ஹென்டர்சன் , அமைச்சகம் ஆஃப் அதிக கல்வி , துறை ஆஃப் தொற்று , இயற்கை தகவல்தொடர்புகள் , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய தரகு , லக்ஸம்பர்க் தேசிய ஆராய்ச்சி நிதி ,

Award Celebrates Molecular Pharmacology Studies at LIH


Award Celebrates Molecular Pharmacology Studies at LIH
Dec 31 2020 Read 348 Times
The international 2019 Galien Prize in Pharmacology has been awarded to Luxembourg Institute of Health (LIH) scientists Dr Andy Chevigné and Dr Martyna Szpakowska from the LIH Department of Infection and Immunity (DII) for their outstanding contribution to molecular pharmacology.
Frank Vandenbroucke, Belgian Minister of Public Health and Social Affairs, along with representatives of pharmaceutical companies and healthcare hubs attended the virtual prize ceremony. The two LIH researchers were commended for their continuous achievements over the last eight years in advancing the understanding of the relevance, role, function and pharmacology of atypical chemokine receptors (ACKRs) and their ligands research activities and also for establishing and co-supervising the first molecular pharmacology academic laboratory in Luxembourg, which is located at the LIH Department of Infection and Immu ....

Frank Vandenbroucke , Andy Chevign , Martyna Szpakowska , Public Health , Department Of Infection , Group Leader Of The Immuno , Luxembourg Institute Of Health , Luxembourg Institute , Belgian Minister , Social Affairs , Principal Investigator , Group Leader , Galien Prize , Grand Duchy , Roularta Healthcare , பொது ஆரோக்கியம் , துறை ஆஃப் தொற்று , குழு தலைவர் ஆஃப் தி இம்யூனோ , லக்ஸம்பர்க் நிறுவனம் ஆஃப் ஆரோக்கியம் , லக்ஸம்பர்க் நிறுவனம் , பெல்ஜியன் அமைச்சர் , சமூக வாழ்க்கைத்தொழில்கள் , ப்ரிந்ஸிபல் புலனாய்வாளர் , குழு தலைவர் , காலியன் ப்ரைஸ் ,