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New study further advances the treatment of chronic pain

Scientists from the Immuno-Pharmacology and Interactomics group at the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. The researchers also developed a synthetic analogue of conolidine, RTI-5152-12, which displays an even greater activity on the receptor. ....

Andy Chevign , Ojas Namjoshi , Martyna Szpakowska , Markus Ollert , Ministry Of Higher Education , Department Of Infection , Nature Communications , Immunity Of The Luxembourg Institute Health , European Commission , Luxembourg National Research Fund , Luxembourg Institute , Drug Discovery , Signal Transduction , Targeted Therapy , Prof Markus Ollert , Higher Education , Cell Biology , Molecular Biology , Medicine Health , அமைச்சகம் ஆஃப் அதிக கல்வி , துறை ஆஃப் தொற்று , இயற்கை தகவல்தொடர்புகள் , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய தரகு , லக்ஸம்பர்க் தேசிய ஆராய்ச்சி நிதி , லக்ஸம்பர்க் நிறுவனம் ,

Research opens alternative therapeutic avenues for treatment of chronic pain

Building on their previous findings, scientists from the Immuno-Pharmacology and Interactomics group at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), a nonprofit research institute, have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. ....

Andy Chevign , Ojas Namjoshi , Martyna Szpakowska , Markus Ollert , Emily Henderson , Ministry Of Higher Education , Department Of Infection , Nature Communications , Immunity Of The Luxembourg Institute Health , European Commission , Luxembourg National Research Fund , Luxembourg Institute , Drug Discovery , Signal Transduction , Targeted Therapy , Prof Markus Ollert , Higher Education , Chronic Pain , Drug Discovery , எமிலி ஹென்டர்சன் , அமைச்சகம் ஆஃப் அதிக கல்வி , துறை ஆஃப் தொற்று , இயற்கை தகவல்தொடர்புகள் , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய தரகு , லக்ஸம்பர்க் தேசிய ஆராய்ச்சி நிதி ,