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More Support for Gene Assay to Guide Breast Cancer Treatment


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Patients with ultralow-risk breast cancer according to genomic assessment had excellent long-term outcomes regardless of clinical risk or whether they received adjuvant therapy, a new analysis of a randomized trial showed.
The 8-year breast cancer-specific survival (BCSS) was 99.2% among patients classified as clinically high-risk but ultralow-risk by the MammaPrint 70-gene assay. Patients with an ultralow-risk genomic assessment and low clinical risk had an 8-year BCSS of 99.7%. Freedom from distant metastasis at 8 years was 97.6% in patients who were clinically and genomically low-risk versus 95.0% for those who were clinically high-risk but genomically low-risk.
In patients with an ultralow-risk genomic assessment, the 8-year distant metastasis-free interval (DMFI) rate was 97.8% with no adjuvant systemic therapy. That compared with an 8-year DMFI of 97.4% in patients who received only adjuvant endocrine therapy and 94.9% in patients who received ....

United States , Noord Holland , Priya Rastogi , Charles Bankhead , Josephine Lopes Cardozo , National Surgical Adjuvant Breast , American Society Of Clinical Oncology , University Of Pittsburgh , Netherlands Cancer Institute , American Society , Clinical Oncology , Surgical Adjuvant Breast , Bowel Project , Medpage Today , Endocrine Therapy , Breast Cancer , ஒன்றுபட்டது மாநிலங்களில் , நூற்த் ஹாலண்ட் , பிரியா ரஸ்டோகி , சார்லஸ் வங்கித் தலை , ஜோசபின் லோப்ஸ் கார்டோசோ , அமெரிக்கன் சமூகம் ஆஃப் மருத்துவ புற்றுநோயியல் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , நெதர்லாந்து புற்றுநோய் நிறுவனம் , அமெரிக்கன் சமூகம் , மருத்துவ புற்றுநோயியல் ,

Less Treatment May Be Fine for Some Women With Breast Cancer


December 10, 2020
Postmenopausal women may be able to skip some treatments, thereby avoiding some debilitating side effects, new research says. 
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It may be possible for some postmenopausal women to avoid some breast cancer treatment without compromising survival, according to two new studies presented at the San Antonio Breast Cancer Symposium (SABCS), hosted by UT Health San Antonio, the American Association for Cancer Research, and the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine.
The meeting was held virtually December 8 to 11.
One study found that postmenopausal women with early-stage breast cancer who were at low risk of recurrence can skip chemotherapy after surgery. The other found that older patients may be able to skip radiation therapy following breast-conserving surgery. ....

Ann Arbor , United States , United Kingdom , San Antonio , Baylor College Of Medicine , University Of Texas , City Of , Kevin Kalinsky , Priya Rastogi , C Kent Osborne , Reshma Jagsi , Ian Kunkler , National Surgical Adjuvant Breast , University Of Edinburgh , University Of Michigan , American Association For Cancer Research , University Of Pittsburgh , Cancer Research Network , Ut Health San Antonio , Sciences In Medicine , University Of Texas Health Sciences Center , San Antonio Breast Cancer Symposium , American Association , Cancer Research , Comprehensive Cancer Center , Baylor College ,