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Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation

Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation
plos.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from plos.org Daily Mail and Mail on Sunday newspapers.

United States , Dnase Rnase , Novogene Sacramento , Peter Breen , Calcofluor White , Seanp Curran , Hamamatsu Orcafusion , Andrea Azcarate , Sarah Torzone , Monica Macharios , Kristenk White , Eyleen Orourke , Thermo Fisher , Caenorhabditis Genetics Center , Laboratory Medicine , Lineberger Comprehensive Cancer Center , Nutrition Obesity Research Center , Cancer Center Core Support Grant , Office Of Research Infrastructure Programs , Department Of Pathology , Microscopy Services Laboratory , Soil Red , Gibson Assembly , Ted Pella Inc , University Of Southern California , Kombucha Tea ,

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair factors, Polθ function is activated in mitosis upon phosphorylation by Polo-like kinase 1 (PLK1). Phosphorylated Polθ is recruited by a direct interaction with the BRCA1 C-terminal domains of TOPBP1 to mitotic DSBs, where it mediates joining of broken DNA ends. Loss of Polθ leads to defective repair of mitotic DSBs, resulting in a loss of genome integrity. This is further exacerbated in ....

United States , Hela Gibco , Biotinylated Pol , Orbitrap Exploris , Lipofectamine Rnaimax Thermofisher , Jn Mark Glover , Mai Tai Deepsee , Giemsa Karyomax , Institut Curie , Jena Bioscience , Roper Zeiss , Ge Healthcare , Analysis Software , Proteomexchange Consortium , Magnetic Resonance Data Bank , C Terminal Flag P , Babe Blast , System Biosciences , Thermofisher Scientific , Santa Cruz Biotechnology , Cell Signaling , Novus Biologicals , Bethyl Laboratories , Spectra Physics , Mai Tai Laser , Omplete Protease Inhibitor Cocktail ,

The positioning mechanics of microtubule asters in Drosophila embryo explants

The positioning mechanics of microtubule asters in Drosophila embryo explants
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Sophie Theis , Gianluca Grenci , Physik Instrumente , M Bettencourt Dias , Virgile Viasnoff , Calouste Gulbenkian , Eppendorf Femtojet , Tetsuya Hiraiwa , Thomas Surrey , Andor Zyla , Jacques Prost , Partnership Agreement European Regional Development Fund , Human Frontiers Science Program , European Commission , Bloomington Drosophila Stock Center , Lisboa Regional Operational Program , Molecular Devices Inc , Technical Support Service , Nikon Eclipse Ti E , Plan Fluor , Plan Apo , Nenad Pavin , Fly Facility , Advanced Imaging Facility , European Regional Development Fund ,

Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration

Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration. ....

United States , Harvard University , Stanford University , Tufts University , Paola Bovolenta , Takara Bio , Henri Leinonen , Tirin Moore , Norbert Ghyselinck , Aldh Flox , States Elizabethton , Anneg Lefler , Jackson Immunoresearch , Andor Zyla , Constancel Cepko , Ryoji Amamoto , John Flannery , University Of California , Drummond Scientific Company , Electron Microscopy Sciences , National Eye Institute , Jackson Laboratory , Blavatnik Institute , Harvard Medical School , Nikon Elements Acquisition Software , Fisher Scientific ,

A biological nanofoam: The wall of coniferous bisaccate pollen

A biological nanofoam: The wall of coniferous bisaccate pollen
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , City Of , Haute Normandie , Christine Moriscot , Molecular Biology Laboratory , Grenoble Partnership For Structural Biology , Natural History Museum , Partnership For Soft Condensed Matter , Asylum Research , Kildonnan Member , Lealt Shale Formation , Middle Jurassic , Nikon Eclipse , Plan Apo , Soft Condensed Matter , Oxford Instruments , Zeiss Crossbeam , Thermo Fisher Scientific Titan Themis , Helmholtz Metadata Collaboration Hub Matter , European Molecular Biology Laboratory , Grenoble Partnership , Guy Schoehn , Alpes Region , Fondation Recherche Medicale , French Infrastructure , Integrated Structural Biology ,