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Aging affects immune response and virus dynamics in COVID-19 patients, study finds

A study examining 1031 hospitalized COVID-19 patients found that aging significantly impacts immune responses, viral dynamics, and the nasal microbiome, with older adults experiencing more severe disease symptoms and delayed viral clearance. ....

United States , Science Translational Medicine , Corona Borealis Studio , Severe Acute Respiratory Syndrome Coronavirus , Phenotyping Assessment , Covid 19 , Immune Response , Interleukin 6 , Ars Cov 2 ,

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
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United States , Oklahoma City , University Of California San Francisco , New South Wales , New York , Baylor College Of Medicine , Heidi Erickson , Brenda Barton , Ramin Salehi Rad , Nataliya Melnyk , Nathan Grubaugh , Farrah Kheradmand , Charles Dela Cruz , Keith Farrugia , Zain Khalil , Arthur Viode , Nelsoni Agudelo Higuita , Prescottg Woodruff , Elizabeth Beagle , Matthewl Anderson , Albertc Shaw , Randi Vita , Bernadine Panganiban , Scott Sieg , Angela Rogers , Susan Pereira Ribeiro ,

Why Does COVID-19 Cause Severe Illness in Some Patients but Not Others?

A new study harnesses big data and bioinformatics to explore how the immune system can fight off the virus in some cases and fails in others. ....

Anderson Brito , Anna Konstorum , Chris Cotsapas , Ruthr Montgomery , Stevenh Kleinstein , Anthonyn Brady , Leying Guan , Nathan Grubaugh , Bernie Chen , Albertc Shaw , Denise Esserman , Shrikant Pawar , Jeremyp Gygi , Davida Hafler , Lois Stiles Edgerly , National Institute Of Allergy , Human Immunology Project Consortium , Phenotyping Assessment , National Institute , Infectious Diseases , Lois Stiles Edgerly Professor , Cell Reports Medicine , Phenotying Assessment , Post Acute Sequelae ,

Biological data may help doctors predict the severity of COVID-19 in their patients

Scientists have now made substantial progress in predicting the path that COVID-19 will take in patients, finding sets of biological features that are associated with the course and severity of COVID-19. The findings were recently published in Cell Reports Medicine by researchers from Drexel University s College of Medicine, Boston Children s Hospital, Yale, and other institutions nationwide. ....

United States , Charles Cairns , Tedros Adhanom Ghebreyesus , Elias El Haddad , Tel Haddad , College Of Medicine , Drexel University College Of Medicine , World Health Organization , Cell Reports Medicine , Drexel University , Boston Children , Leonore Annenberg Dean , Phenotyping Assessment ,