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Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Oklahoma City , University Of California San Francisco , New South Wales , New York , Baylor College Of Medicine , Heidi Erickson , Brenda Barton , Ramin Salehi Rad , Nataliya Melnyk , Nathan Grubaugh , Farrah Kheradmand , Charles Dela Cruz , Keith Farrugia , Zain Khalil , Arthur Viode , Nelsoni Agudelo Higuita , Prescottg Woodruff , Elizabeth Beagle , Matthewl Anderson , Albertc Shaw , Randi Vita , Bernadine Panganiban , Scott Sieg , Angela Rogers , Susan Pereira Ribeiro ,

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , South Africa , United Kingdom , Randi Vita , Ben Kiefel , Carolee Lee , Matt Beasley , Jasona Greenbaum , Pramila Rijal , Jack Wang , Pete Smith , Shahrad Daraeikia , Nathan Eisel , David Beaumont , Vincent Dussupt , Luo Yang , Lisa Schimanski , Bjoern Peters , Mahita Jarjapu , Mari Kojima , Karen Makar , Mark Sampson , Sindy Liao , Chanjuan Liu , Alain Townsend , Latonya Williams ,

A COVID-fighter's guide to T cells

Credit: CDC
LA JOLLA In a new paper, scientists from La Jolla Institute for Immunology (LJI) bring together research findings from COVID-19 researchers around the world. The results are striking: human T cells can target more than 1,400 sites on the SARS-CoV-2 virus.
Our lab and many others have shown this very broad and diverse T cell response, says LJI Research Assistant Professor Daniela Weiskopf, Ph.D., co-author of the
Cell Host & Microbe review.
This kind of research review, called a meta-analysis, pools the results of multiple studies, and the researchers give close consideration to how the studies were conducted.
In the case of COVID-19, a global meta-analysis of T cell response studies is especially helpful because different patient populations can have vastly different immune responses, based on their genetic differences and past disease history. ....

Randi Vita , Shane Crotty , Alba Grifoni , Bjoern Peters , John Sidney , Alessandro Sette , Research Assistant Professor Daniela Weiskopf , National Institute Of Health , National Institute Of Allergy , Jolla Institute For Immunology , Vaccine Research , Assistant Professor Daniela Weiskopf , Cell Host , Infectious Disease , Immune Epitope Database , National Institute , Infectious Diseases , ஷேன் க்ரோட்டி , ஜான் சிட்னி , Alessandro செத்தே , தேசிய நிறுவனம் ஆஃப் ஆரோக்கியம் , தேசிய நிறுவனம் ஆஃப் ஒவ்வாமை , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , தடுப்பூசி ஆராய்ச்சி , செல் தொகுப்பாளர் , தொற்று நோய் ,