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Print Scientists at Scripps Research in La Jolla have demonstrated a promising new strategy for treating lymphomas, a group of cancers that begin in infection-fighting cells of the immune system called lymphocytes. The new approach uses natural cancer-targeting immune cells, known as natural “killer cells,” that have been modified to selectively target lymphoma. As described in the scientists’ study, published in the journal Angewandte Chemie, the modified natural killer cells brought about a dramatic reduction of lymphoma in a mouse. “We found a way to achieve selectivity in targeting lymphoma cells, which is an important departure from existing therapies,” said co-senior author Peng Wu, an associate professor in the department of molecular medicine at Scripps Research. ....
Scientists demonstrate a promising strategy for treating lymphomas Scientists at Scripps Research have demonstrated a promising new strategy for treating lymphomas, a group of cancers that begin in infection-fighting cells of the immune system called lymphocytes. The new approach uses natural cancer-targeting immune cells, known as natural killer cells, that have been modified to selectively target lymphoma. As described in their study, published in the journal Angewandte Chemie, the modified natural killer cells brought about a dramatic reduction of lymphoma in a mouse. We found a way to achieve selectivity in targeting lymphoma cells, which is an important departure from existing therapies, says co-senior author Peng Wu, PhD, an associate professor in the Department of Molecular Medicine at Scripps Research. ....
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E-Mail IMAGE: A heavy layer of glycans, seen here in green, cover immune cells and provide a way to target cancer-specific markers in the body. view more Credit: Image courtesy of Senlian Hong, Wu Lab at Scripps Research LA JOLLA, CA Scientists at Scripps Research have demonstrated a promising new strategy for treating lymphomas, a group of cancers that begin in infection-fighting cells of the immune system called lymphocytes. The new approach uses natural cancer-targeting immune cells, known as natural killer cells, that have been modified to selectively target lymphoma. As described in their study, published in the journal Angewandte Chemie, the modified natural killer cells brought about a dramatic reduction of lymphoma in a mouse. ....