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Scientists unveil new Ebola virus vaccine design

Scientists unveil new Ebola virus vaccine design Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health. In the new design, described in a paper in Nature Communications, copies of the Ebola virus outer spike protein, known as the glycoprotein, are tethered to the surface of a spherical carrier particle. The resulting structure resembles the spherical appearance of common RNA viruses that infect humans and is starkly different from the snake-like shape of the Ebola virus. The scientists say the design is intended to stimulate a better protective immune response than standard vaccine approaches, which often expose the immune system to individual glycoproteins rather than realistic-looking virus particles.

Innovative Approach for Ebola Vaccine Design

Read Time: Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health. In the new design, described in a paper in  Nature Communications, copies of the Ebola virus outer spike protein, known as the glycoprotein, are tethered to the surface of a spherical carrier particle. The resulting structure resembles the spherical appearance of common RNA viruses that infect humans—and is starkly different from the snake-like shape of the Ebola virus. The scientists say the design is intended to stimulate a better protective immune response than standard vaccine approaches, which often expose the immune system to individual glycoproteins rather than realistic-looking virus particles.

Scripps Research offers new way to visualize the spread of variants

Scripps Research offers new way to visualize the spread of variants San Diego team offers eagle-eye view of variants Scientists at Scripps Research have unveiled a new online tool to visualize the latest variants and track newly emerging mutations. and last updated 2021-02-25 20:41:20-05 SAN DIEGO (KGTV) As we attack the spread of the coronavirus with vaccines, our enemy is adapting, picking up a new mutation in its genetic code roughly every two weeks. Scientists at Scripps Research have unveiled a new online tool to visualize the latest variants and track newly emerging mutations. The mutation tracking tool is the latest addition to outbreak.info from the Center for Viral Systems Biology (CViSB) at Scripps. Through maps and charts, users can track the spread of variants like B.1.1.7 country by country, state by state.

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Scientists unravel the workings of a mysterious protein implicated in movement disorders Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders. The findings, which appear in Cell Reports, are an advance in the basic understanding of how the brain controls muscles and could lead to treatments for children born with Gαo-mutation movement disorders. Such conditions known as GNAO1-related neurodevelopmental disorders were discovered only in the past decade, and are thought to affect at least hundreds of children around the world. Children with the disease suffer from severe developmental delays, seizures and uncontrolled muscle movements.

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