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Study shows when people with cerebral palsy are most likely to break bones


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Researchers at Michigan Medicine found a subset of middle-aged men with cerebral palsy are up to 5.6 times more likely to suffer fractures than men without the disorder.
We are not really sure why this happens, said Edward A. Hurvitz, M.D., professor and chair of the Michigan Medicine Department of Physical Therapy and Rehabilitation. It may be related to structural differences that occur during adolescent growth, or to greater bone mineral loss at earlier age for people with cerebral palsy compared to peers.
For a study published in
BONE, the team examined the timing and site of bone fractures for around 10 million people with and without cerebral palsy using public and private insurance claims from 2016. They found people with the disability have fragile bones that present high fracture risk, but at different times across the lifespan compared to the general population. ....

United States , Daniel Whitney , Helenl Gehring , Edwarda Hurvitz , Michigan Medicine Department Of Orthopaedic Surgery , Michigan Medicine Department Of Physical Therapy , Michigan Medicine , Michigan Medicine Department , Physical Therapy , Orthopaedic Surgery , Medicine Health , Health Care Systems Services , Health Professionals , Orthopedic Medicine , Disabled Persons , ஒன்றுபட்டது மாநிலங்களில் , டேனியல் விட்னி , மிச்சிகன் மருந்து , மிச்சிகன் மருந்து துறை , உடல் சிகிச்சை , எலும்பியல் அறுவை சிகிச்சை , மருந்து ஆரோக்கியம் ,

ALS development could be triggered by loss of network connections in the spinal cord


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IMAGE: The spinal cord of a mouse with ALS. The green cells are inhibitory interneurons.
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Credit: Ilary Allodi, University of Copenhagen
ALS is a very severe neurodegenerative disease in which nerve cells in the spinal cord controlling muscles and movement slowly die. There is no effective treatment and the average life expectancy after being diagnosed with ALS is usually short. Because of this, new knowledge about the disease is urgently needed.
Now, researchers from the University of Copenhagen have gained new insights about ALS, by investigating the early development of the disease in a mouse model.
We have found that networks of nerve cells in the spinal cord called inhibitory interneurons lose connection to motor neurons, the nerve cells that directly control muscle contraction. We do not yet know if these changes cause the disease. But the loss of the inhibitory signal could explain why the motor neurons end up dying in AL ....

Ilary Allodi , Roser Monta , Nature Communications , University Of Copenhagen , Department Of Neuroscience , Assistant Professor , Ole Kiehn , Cell Biology , Medicine Health , Orthopedic Medicine , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் , துறை ஆஃப் நரம்பியல் , உதவியாளர் ப்ரொஃபெஸர் , ஓல் கீஹ்ன் , செல் உயிரியல் ,