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E-Mail IMAGE: The spinal cord of a mouse with ALS. The green cells are inhibitory interneurons. view more Credit: Ilary Allodi, University of Copenhagen ALS is a very severe neurodegenerative disease in which nerve cells in the spinal cord controlling muscles and movement slowly die. There is no effective treatment and the average life expectancy after being diagnosed with ALS is usually short. Because of this, new knowledge about the disease is urgently needed. Now, researchers from the University of Copenhagen have gained new insights about ALS, by investigating the early development of the disease in a mouse model. We have found that networks of nerve cells in the spinal cord called inhibitory interneurons lose connection to motor neurons, the nerve cells that directly control muscle contraction. We do not yet know if these changes cause the disease. But the loss of the inhibitory signal could explain why the motor neurons end up dying in AL ....