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Nuclear morphology is shaped by loop-extrusion programs

It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1–3. However, how polymorphonuclear structures are assembled remains unknown4. Here we show that in neutrophil progenitors, halting loop extrusion—a motor-powered process that generates DNA loops by pulling in chromatin5—leads to the assembly of polymorphonuclear genomes. Specifically, we found that in mononuclear neutrophil progenitors, acute depletion of the loop-extrusion loading factor nipped-B-like protein (NIPBL) induced the assembly of horseshoe, banded, ringed and hypersegmented nuclear structures and led to a reduction in nuclear volume, mirroring what is observed during the differentiation of neutrophils. Depletion of NIPBL also induced cell-cycle arrest, activated a neutrophil-specific gene program and conditioned a loss of interactions across topologically associating domains to generate a chromatin architecture that resemble ....

Elie Metchnikoff , Ok Organization , Cell Biol , Untersuchungen Des , Cornelia De Lange , Acids Res ,

JK Lakshmi Cement's net profit dips 30.66% in Q1 FY24, Real Estate News, ET RealEstate

JK Lakshmi Cement s net consolidated total income stood at Rs 1,741.38 crore in Q1 FY24, a growth of 4.84 per cent from Rs 1,661.05 crore it recorded in the similar quarter last year. ....

State Of Rajasthan , Vinita Singhania , Jk Organization , Renewable Energy , Industries For Rs , Hidrive Developers , Renewable Power , Solar Power Plant , Solar Power Project , Durg Plant , Udaipur Cement Works , Clinkerisation Line , Rights Issue , Jk Lakshmi Cement , K Lakshmi Cement Results , Jk Lakshmi Cement Profit , Ok Organization , Vinita Singhania ,

Valenzuela's COMET shuttles to give commuters free rides until Jan. 31 – Manila Bulletin

Residents of Valenzuela City can enjoy the free rides on the city’s electric minibuses only until Jan. 31, the local government announced on Saturday, Jan. 15.
First launched in Dec. 2021, the “COMET” shuttles or fully- airconditioned with charging stations electric vehicles had served resident com ....

Valenzuela City , City Of Valenzuela , Cherrylin Caacbay , Puregold Dalandanan , Puregold Malanday , Puregold Valenzuela , App On Store Or Play , Ok Organization , Global Electric Transport , App Store , Play Store , Ayala Malls The ,

โตสวนวิกฤตโควิด ซี.พี.ส่งออกข้าวขึ้นแท่นเบอร์ 2

โตสวนวิกฤตโควิด ซี.พี.ส่งออกข้าวขึ้นแท่นเบอร์ 2
prachachat.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prachachat.net Daily Mail and Mail on Sunday newspapers.

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gujarat bjp leaders protest against attack in west bengal, but did not see the hardships of the corona patient of gujarat | ગુજરાત ભાજપના નેતાઓને બંગાળનો અત્યાચાર દેખાયો, પણ ગુજરાતની જનતાની હાડમારી ના દેખાઈ?

gujarat bjp leaders protest against attack in west bengal, but did not see the hardships of the corona patient of gujarat | ગુજરાત ભાજપના નેતાઓને બંગાળનો અત્યાચાર દેખાયો, પણ ગુજરાતની જનતાની હાડમારી ના દેખાઈ?
divyabhaskar.co.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from divyabhaskar.co.in Daily Mail and Mail on Sunday newspapers.

Ok Organization , Bharatiya Janata Party , Gujarat Statee Center , Government Accumulation , West Bengal , West Bengal Indian , Act Gujarat , Gujarat State , பாரதியா ஜனதா கட்சி , மேற்கு பெங்கல் , மேற்கு பெங்கல் இந்தியன் , குஜராத் நிலை ,